About this Research Topic
This Frontiers Research Topic emerges as an outcome of themes covered during the annual meeting of the Argentinean Society of Physiology (SAFIS; https://safisiol.org.ar) and is targeted to highlight physiological and pathophysiological studies focused on the interrelation between health, stress and disease and the molecular pathways that either favor, break or reverse this unidirectional path, illustrating new physiological principles or mechanisms.
Cells, tissues, organs and animals are continuously subdued to different forms of stress (mechanical, oxidative, radiation, nervous, etc.) and have developed physiological mechanisms to cope with their sustained influence. However, when these mechanisms fail or the stressor is abnormally amplified, an otherwise healthy system is driven to disease. The goal of this article collection is to understand the underlying mechanisms triggered by stress that lead to disease and to provide innovative approaches to study, treat and reverse its deleterious impact. Contributions that use animal, cellular and molecular approaches to shed light on pathophysiological mechanisms triggered by stress and that contribute to their understanding will provide new potential avenues for the control of the adverse outcomes associated with pathological stress.
We also welcome work performed in lower vertebrate or invertebrate models (eg. Drosophila, C. elegans and zebrafish), as long as they explore human pathology themes. This Research Topic is also open to theoretical modeling papers oriented to further our understanding of physiopathological processes. Studies that have a translational perspective and contribute to closing the gap between health and disease through a physiological approach are of special interest.
Manuscripts at the molecular level, cell membrane, single cells, tissues or organs are all encouraged.
Cells, tissues, organs and animals are continuously subdued to different forms of stress (mechanical, oxidative, radiation, nervous, etc.) and have developed physiological mechanisms to cope with their sustained influence. However, when these mechanisms fail or the stressor is abnormally amplified, an otherwise healthy system is driven to disease. The goal of this article collection is to understand the underlying mechanisms triggered by stress that lead to disease and to provide innovative approaches to study, treat and reverse its deleterious impact. Contributions that use animal, cellular and molecular approaches to shed light on pathophysiological mechanisms triggered by stress and that contribute to their understanding will provide new potential avenues for the control of the adverse outcomes associated with pathological stress.
We also welcome work performed in lower vertebrate or invertebrate models (eg. Drosophila, C. elegans and zebrafish), as long as they explore human pathology themes. This Research Topic is also open to theoretical modeling papers oriented to further our understanding of physiopathological processes. Studies that have a translational perspective and contribute to closing the gap between health and disease through a physiological approach are of special interest.
Manuscripts at the molecular level, cell membrane, single cells, tissues or organs are all encouraged.
Keywords: mechanotransduction, signalling, stress, remodeling, cell death and disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
