About this Research Topic
Prostate cancer is one of the most common cancers affecting the male population, it remains a significant scientific and clinical challenge which continues to have poor survival and prognosis for patients. Although groundbreaking scientific discoveries have paved the way for a better therapeutic efficacy by targeting key features of disease, and advances in genetic screening and early diagnosis have greatly improved the outlook for patients, prostate cancer still remains a leading cause of cancer-associated death in men worldwide. Dealing with prostate cancer generally involves the management of individualized therapeutic strategies dependent on the characteristics of the disease such as slow-growing, indolent tumor versus aggressive disease and tumor progression or recurrence. Prostate cancer research is a very active area of multidisciplinary investigation and translational research aimed for optimal results on disease management, quality of life and patient survival. A major concern to the health care system is the acquisition of resistance to standard care, that occurs in a substantial percentage of patients.
From these premises, and in light of the general increase in the incidence of prostate cancer in the global population of western countries, it is evident that prevention may be the most rewarding strategy. Therefore, we would like to open the debate in the prostate cancer research field by shifting the focus from how to treat, to how to prevent the disease. In fact, many risk factors have been found associated with prostate cancer onset and development, showing that this disease is largely preventable.
The aim of this Research Topic is to invite researchers who can share their latest findings with the wider scientific community concerning all conceivable aspects of prostate cancer prevention and research that addresses multidisciplinary approaches. We welcome Original Research, Reviews, Systematic Reviews, Mini-Reviews and Perspective articles which highlight the latest advances in prostate cancer prevention research, discussing the implications of these findings for people’s health, and the health systems. Areas of interest include, but are not limited to, the following fields of research on prostate cancer onset and progression, and the underlying molecular mechanisms:
-Chemoprevention, including off-label strategies for drugs, natural compounds and avoidable risk factors
-Nutrition, intended as bio-actives, healthy lifestyle, lifestyle modification, education
-Environmental factors, pollutants and biological risk factors linked to pathogens, such as virus and bacteria
-Alteration and reprogramming of prostate metabolism
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
From these premises, and in light of the general increase in the incidence of prostate cancer in the global population of western countries, it is evident that prevention may be the most rewarding strategy. Therefore, we would like to open the debate in the prostate cancer research field by shifting the focus from how to treat, to how to prevent the disease. In fact, many risk factors have been found associated with prostate cancer onset and development, showing that this disease is largely preventable.
The aim of this Research Topic is to invite researchers who can share their latest findings with the wider scientific community concerning all conceivable aspects of prostate cancer prevention and research that addresses multidisciplinary approaches. We welcome Original Research, Reviews, Systematic Reviews, Mini-Reviews and Perspective articles which highlight the latest advances in prostate cancer prevention research, discussing the implications of these findings for people’s health, and the health systems. Areas of interest include, but are not limited to, the following fields of research on prostate cancer onset and progression, and the underlying molecular mechanisms:
-Chemoprevention, including off-label strategies for drugs, natural compounds and avoidable risk factors
-Nutrition, intended as bio-actives, healthy lifestyle, lifestyle modification, education
-Environmental factors, pollutants and biological risk factors linked to pathogens, such as virus and bacteria
-Alteration and reprogramming of prostate metabolism
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: prostate cancer, prevention treatment, therapeutics, oncology, cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
