About this Research Topic
The development of new blood vessels, angiogenesis, is involved in both physiological repair and pathological processes throughout life. Angiogenesis is recognized as a critical process in tissue expansion and repair. New blood vessels can improve local microcirculation and restore blood supply to ischemic areas, making them a crucial therapeutic measure for ischemic disease relief. Pharmacological interventions that can balance excess and insufficient angiogenesis by regulating pathways and expression of specific genes, are key to slow disease progression, extend patients' lives, and prevent adverse events. Latest research efforts have been focusing both on combining existing drugs to investigate new pharmacological effects and mechanisms in angiogenesis, as well as on identifying new potential targets and drugs.
In this Research Topic, we aim to explore cellular and molecular mechanisms of angiogenesis in the pathogenesis of ischemic diseases. We aim to gather Original Research articles that report new mechanisms of angiogenesis regulation in ischemic diseases, reveal new regulatory targets and identify potential drugs to regulate angiogenesis. Review articles that systematically summarize the regulatory signaling network of angiogenesis in ischemic diseases are also welcome.
We encourage authors to submit manuscripts that focus on, but are not limited to, the subtopics listed below:
• Cellular and molecular mechanisms underlying the role of angiogenesis in the genesis and development of ischemic diseases;
• Gene regulatory and signaling networks that promote or attenuate angiogenesis in ischemic diseases;
• Pharmacological interventions for the treatment of ischemic diseases through angiogenesis;
• Signal transduction, new targets and therapies for ischemic diseases;
• New methods to detect angiogenesis in patients with ischemic diseases;
• Adverse reactions or side effects of angiogenesis-related therapies.
In this Research Topic, we aim to explore cellular and molecular mechanisms of angiogenesis in the pathogenesis of ischemic diseases. We aim to gather Original Research articles that report new mechanisms of angiogenesis regulation in ischemic diseases, reveal new regulatory targets and identify potential drugs to regulate angiogenesis. Review articles that systematically summarize the regulatory signaling network of angiogenesis in ischemic diseases are also welcome.
We encourage authors to submit manuscripts that focus on, but are not limited to, the subtopics listed below:
• Cellular and molecular mechanisms underlying the role of angiogenesis in the genesis and development of ischemic diseases;
• Gene regulatory and signaling networks that promote or attenuate angiogenesis in ischemic diseases;
• Pharmacological interventions for the treatment of ischemic diseases through angiogenesis;
• Signal transduction, new targets and therapies for ischemic diseases;
• New methods to detect angiogenesis in patients with ischemic diseases;
• Adverse reactions or side effects of angiogenesis-related therapies.
Keywords: angiogenesis, signaling, ischemic disease, pharmacological interventions, cellular and molecular mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
