About this Research Topic
Biotechnology and bioengineering have recently witnessed significant advancements in several areas, one of the most extensively-studied ones being the manufacturing of next-generation biologics. Those developments are the result of the synergistic contribution of both academic and industrial efforts focusing on multiple aspects of the drug manufacturing process. The success of currently emerging and established approaches and technologies in the field of biologics such as cancer immunotherapies, gene-therapy, mRNA delivery and erythrocytes-based drug delivery is largely dependent on the scaled manufacturing of high-quality biomacromolecules and cells. Thus, it is of prime importance to facilitate scientific communication among different groups and promote collaborative thinking around those efforts.
The current Research Topic is focusing on the “Manufacturing of the Next-Generation Biologics” by capturing milestone findings from both Industrial Biotechnology and Bioprocess Engineering to better serve academic & industrial communities.
The goal of the present Research Topic is to capture important information related to advancements in the field of “Manufacturing of Next-Generation Biologics”. Process optimization, downstream processing & purification optimization, formulation, PEGylation, antibody-conjugates, and Chemistry-Manufacturing-Controls (CMC) are just some topic examples that the current collection aims to cover. These methodologies are of particular interest in the following fields (but are not limited to): 1) cancer immunotherapy and the manufacturing of immune-checkpoint inhibitor antibodies; 2) gene therapy and the manufacturing of viral vectors; 3) mRNA delivery and 4) erythrocyte-based encapsulation of biologics. Cutting-edge, ongoing research in these fields will be selected for publication in this collection through the peer-review process, envisioning to add more to the fast-paced, growing broader area of bioengineering and biotechnology.
The Research Topic 'Manufacturing of Next Generation Biologics' welcomes submissions related, but not limited to, the following areas:
• Process optimization
• Downstream processing
• Chemistry-Manufacturing-Controls (CMC)
• Gene therapy methodologies including viral vector production
• mRNA delivery
• Protein PEGylation optimization
• Biologics encapsulation on erythrocytes
• Generation & optimization of antibody-drug-conjugates
The current Research Topic is focusing on the “Manufacturing of the Next-Generation Biologics” by capturing milestone findings from both Industrial Biotechnology and Bioprocess Engineering to better serve academic & industrial communities.
The goal of the present Research Topic is to capture important information related to advancements in the field of “Manufacturing of Next-Generation Biologics”. Process optimization, downstream processing & purification optimization, formulation, PEGylation, antibody-conjugates, and Chemistry-Manufacturing-Controls (CMC) are just some topic examples that the current collection aims to cover. These methodologies are of particular interest in the following fields (but are not limited to): 1) cancer immunotherapy and the manufacturing of immune-checkpoint inhibitor antibodies; 2) gene therapy and the manufacturing of viral vectors; 3) mRNA delivery and 4) erythrocyte-based encapsulation of biologics. Cutting-edge, ongoing research in these fields will be selected for publication in this collection through the peer-review process, envisioning to add more to the fast-paced, growing broader area of bioengineering and biotechnology.
The Research Topic 'Manufacturing of Next Generation Biologics' welcomes submissions related, but not limited to, the following areas:
• Process optimization
• Downstream processing
• Chemistry-Manufacturing-Controls (CMC)
• Gene therapy methodologies including viral vector production
• mRNA delivery
• Protein PEGylation optimization
• Biologics encapsulation on erythrocytes
• Generation & optimization of antibody-drug-conjugates
Keywords: Next-Generation Biologics, Bioprocessing, Manufacturing, Cancer, mRNA, Drug Delivery
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
