About this Research Topic
Ferroptosis, a form of programmed cell death discovered in 2012, stimulates ferroptosis of cancer cells to reverse drug resistance and may be developed as a potential strategy for cancer therapy. However, the roles and signaling pathways of ferroptosis in cancer, especially in tumor metastasis, tumor microenvironment, and immune escape, remain unclear. Dysregulation of ferroptosis-associated genes confers the resistance to ferroptosis in tumor cells. However, the mechanisms of ferroptosis-associated gene regulation are not fully understood.
This Research Topic aims to provide a comprehensive overview of the new roles and signaling pathways of ferroptosis in carcinogenesis, metastasis, tumor microenvironment and immune escape, and provide new insights into the regulation of ferroptosis-associated genes at transcriptional, post-transcriptional, translational and post-translational levels in cancer.
We welcome discussions covering, but not limited to, the following aspects:
• New roles and signaling pathways of ferroptosis in carcinogenesis and tumor metastasis
• New roles and signaling pathways of ferroptosis in tumor microenvironment and immune escape
• New mechanisms to regulate ferroptosis-associated genes at transcriptional (transactivation or trans-inactivation) and post-transcriptional (including RNA stability or other mechanisms) levels in cancer
• New mechanisms to regulate ferroptosis-associated genes at translational and post-translational (including protein stability, protein modification or other mechanisms) levels in cancer
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
This Research Topic aims to provide a comprehensive overview of the new roles and signaling pathways of ferroptosis in carcinogenesis, metastasis, tumor microenvironment and immune escape, and provide new insights into the regulation of ferroptosis-associated genes at transcriptional, post-transcriptional, translational and post-translational levels in cancer.
We welcome discussions covering, but not limited to, the following aspects:
• New roles and signaling pathways of ferroptosis in carcinogenesis and tumor metastasis
• New roles and signaling pathways of ferroptosis in tumor microenvironment and immune escape
• New mechanisms to regulate ferroptosis-associated genes at transcriptional (transactivation or trans-inactivation) and post-transcriptional (including RNA stability or other mechanisms) levels in cancer
• New mechanisms to regulate ferroptosis-associated genes at translational and post-translational (including protein stability, protein modification or other mechanisms) levels in cancer
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: Ferroptosis, Carcinogenesis, Metastasis, Tumor microenvironment, Immune escape, Ferroptosis-associated genes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
