Cause or Effect: Role of Inflammation in Metabolic Disorder

Immune response and metabolic regulation are fundamental and highly conserved throughout species. Metabolic inflammatory syndrome includes atherosclerosis, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD) and obesity/overweight. During the past decade, it became clear that inflammation and microenvironment play a key role in metabolic syndrome. Such dysmetabolism results in chronic low-grade inflammation, an important hallmark of metabolic disorder. Many key players resulting in metabolic inflammation have been identified suggesting the need for nutritional intervention. However, to develop effective therapeutic/nutritional intervention strategies it is essential to explore the cause-and-effect relationship between the state of inflammation and the components that are involved metabolic disorder.



This Research Topic will bring together recent work exploring the role of inflammation in metabolic disorders such as obesity/overweight, diabetes mellitus, NAFLD, and others. We welcome both original papers and up-to-date reviews and mini reviews that cover but are not limited to the following topics:

• Role of damage associated molecular pattern (DAMPs) in metabolic disorder.

• Adipose tissue and immune response.

• Regulating metabolic inflammation by nutritional modulation.

• Role of diet and microbiota on metabolic inflammation.

• Triggers, Mechanisms, and Consequences of metabolic inflammation.

• Genome-wide association analysis of inflammatory cytokines for metabolic disorder.

• Therapeutic opportunities for metabolic inflammation.

• Metabolic disorder and impairment of wound healing.