About this Research Topic
The regenerative capability of the central nervous system is limited after traumatic spinal cord injury (SCI) due to intrinsic and extrinsic factors that inhibit spinal cord regeneration, re-myelination, and plasticity, resulting in deficient functional recovery. It has been shown that strategies such as cell, tissue or biomaterial transplantation; neurotrophic factors, gene therapy or other protein or enzyme in situ applications; epidural electric stimulation, rehabilitation, and other single procedures, can promote axonal growth, sprouting and re-myelination, resulting in an improvement in locomotor function. Moreover, neuromodulation therapies through implantable brain-computer interface technologies and rehabilitation augment plasticity of spared circuits and residual projections, also improving functional recovery. It has been shown that, by using combined treatments, axonal regeneration, plasticity, re-myelination, and locomotor function recovery increases in comparison to single treatments. This has underlined the suitability of simultaneously targeting different barriers for spinal cord repairing, in order to obtain better results in SCI animal models and patient recovery.
In most studies where the effect of combined treatment for SCI has been evaluated, two procedures have been used. In the few studies where three procedures were combined, the result was better in comparison to single or dual interventions, which supports the concept that certain combinations may have an additional additive effect. The goal of this Research Topic is to collect Original Research that tests the hypothesis that the combination of two or three concurrent strategies for treating spinal cord injury results in a synergic effect on axonal regrowth, re-myelination, plasticity, and functional recovery. Evaluating the reparative ability of several single and combined treatments targeting some barriers for spinal cord restoration in mammals in both acute and chronic SCI.
For this Research Topic, we welcome articles that show the effect of a combination of two or three concurrent strategies targeting barriers for spinal cord restoration on acute or chronic spinal cord injury. We welcome submissions of Original Research and Systematic Reviews on the following subtopics:
- Cell and/or tissue combination plus biomaterials.
- Cell and/or tissue transplantation combination plus anti-inflammation drugs.
- Cell and/or tissue transplantation combination plus neurotrophic factors.
- Biomaterials plus neurotrophic factors.
- Cell and/or biomaterial combination plus epidural electrical stimulation.
- Cell and/or biomaterial combination plus neurotrophic factors.
- Cell metabolism and rehabilitation program for SCI repairing.
- Cell and gene therapies for SCI
In most studies where the effect of combined treatment for SCI has been evaluated, two procedures have been used. In the few studies where three procedures were combined, the result was better in comparison to single or dual interventions, which supports the concept that certain combinations may have an additional additive effect. The goal of this Research Topic is to collect Original Research that tests the hypothesis that the combination of two or three concurrent strategies for treating spinal cord injury results in a synergic effect on axonal regrowth, re-myelination, plasticity, and functional recovery. Evaluating the reparative ability of several single and combined treatments targeting some barriers for spinal cord restoration in mammals in both acute and chronic SCI.
For this Research Topic, we welcome articles that show the effect of a combination of two or three concurrent strategies targeting barriers for spinal cord restoration on acute or chronic spinal cord injury. We welcome submissions of Original Research and Systematic Reviews on the following subtopics:
- Cell and/or tissue combination plus biomaterials.
- Cell and/or tissue transplantation combination plus anti-inflammation drugs.
- Cell and/or tissue transplantation combination plus neurotrophic factors.
- Biomaterials plus neurotrophic factors.
- Cell and/or biomaterial combination plus epidural electrical stimulation.
- Cell and/or biomaterial combination plus neurotrophic factors.
- Cell metabolism and rehabilitation program for SCI repairing.
- Cell and gene therapies for SCI
Keywords: Spinal cord injury repair, neural restoration, functional recovery, neural transplantation, neural regeneration and plasticity, re-myelination
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
