About this Research Topic
The study of the cellular mechanisms involved in the faithfulness of chromosome segregation, the impact of chromosome missegregation and the resulting aneuploidy on cell physiology, and the contribution of aneuploidy in cancer are areas of intense research. Several breakthrough discoveries have recently emerged providing evidence that chromosome missegregation and aneuploidy are associated with DNA replication and repair, chromosome instability, supernumerary centrosomes, cellular senescence, innate immune response, and resistance to chemotherapy in oncological patients. It has been well established that aneuploidy can affect the initiation and progression of cancer often showing specific patterns of genomic gains and losses based on the tissue of origin, and can act both as a tumor-suppressor or tumor-initiator depending on the cellular and physiological context. The goal of this Research Topic is to assemble original research articles and updated reviews from the different scientific areas converging on this exciting field to foster our knowledge on the causes and consequences of aneuploidy in cancer.
Areas of interest for this Research Topic may include, but are not limited to:
• Cellular mechanisms controlling faithful chromosome segregation.
• New models to study chromosome segregation and aneuploidy.
• Cellular and physiological consequences of aneuploidy and polyploidy.
• Impact of aneuploidy and chromosome instability on cancer.
• Aneuploidy and chromosome instability as prognostic biomarkers in cancer.
Keywords: Aneuploidy, Mitosis, Chromosome segregation, Genome instability, Chromosome instability, Cancer, Prognostic biomarkers
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.