About this Research Topic
Several health conditions are known to affect brain health, yet further investigation needs to be done in order to determine whether dysfunctions in organs other than brain could serve as independent risk factors for brain aging and dementia, or are linked to this risk indirectly, such as through shared risk factors or reverse causality. It is also important to have reliable measures of relevant conditions that are easily implemented to enable early detection and thus allow for early intervention. This could encompass wearable technologies or tests readily administered at general practitioner visits, for which it will help to identify optimal measures from a range of possibilities, such as among those assessing aspects of physical frailty.
This Research Topic aims to publish manuscripts focusing on the possible associations of various health conditions and organ dysfunctions with brain aging and dementia risk, as well as the development, assessment and/or validation of relevant approaches to their measurement. We welcome manuscripts on original investigations in human models, with varying study designs including clinical trials and observational studies. The manuscript should expand the understanding of already known clinical risk factors (e.g. diabetes, heart disease, hearing loss), provide evidence supporting more novel risk factors (e.g. liver disease), or address approaches to their measurement. This collection of manuscripts will be an important step to advance our knowledge of dementia pathogenesis and may lead to the development of new preventive strategies aiming to reduce the burden of dementia in older age.
Keywords: Dementia, Risk, Health, Disorders, Clinical, Aging
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.