About this Research Topic
Membrane proteins and trans-membrane proteins rise in particular the problem of the influence of the external force field on the protein folding process. Polar surrounding of water impels hydrophobic residues to central area of protein forming in this way hydrophobic core. In contrast membrane environment directs hydrophobic residues to protein surface, If the membrane proteins are designed to play the role of trans-membrane channels central part of such protein becomes empty. It makes such structures complicated additionally. This is why every new information taking into account high structural diversity of such proteins is highly expected. The issue is however open for all aspects of the problem and all coming new information will be highly appreciated.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Secondary structure preferences
• Tertiary structure preferences
• Role of external field in structure generation
• Significance of mutations and their influence on biological activity
• Degradation of membrane proteins
• Is it possible to recognise the target environment on the basis of amino acid sequence ?
• Practical applicability to medicine – for instance antibiotic therapy
• Differentiation related to the transported molecule/signal
• Connexins – specificity allowing cell-to-cell junction
• Analysis of structure and function of proteins and as well These involved in relation of proteins and environment
• Studies expressing the influence of the environment on protein folding taking into account both the water and hydrophobic surrounding in the form of external force field
Keywords: Membrane proteins, Transmembrane transport, Porin, Connexin, Rhodopsin, Mechano-sensitive proteins, Channels, Membrane transporters, Role of detergents in analysis; K+/Na+ and Ca2+ channels, Experimental techniques in membrane proteins
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.