About this Research Topic
The lateral skull base which houses the end organs for hearing and balance is harvested post-mortem, is decalcified, embedded in celloidin, and then sectioned at 6-20 microns, stained, mounted and examined. The process requires approximately 12 months after harvest. Several institutions worldwide contain collections of these human temporal bones for histopathological examination to understand otologic and vestibular disease.
These laboratories often contain material accumulated over decades. Specialists who have dedicated their careers to the processing and interpretation of these specimens can each recall special impactful studies which were dear to their hearts. We ask that the contributors use the benefit of 20/20 hindsight to identify the clinically impactful features of their previous work and present them anew with explicit attention to the advancement in our field which those studies enabled.
Each specialist has accumulated special teaching series in their careers. The lessons from these series, and their demonstration with histopictographs, and application to clinical practice would be highly instructive to the neurotologic community.
Temporal bone histopathology has been particularly effective in discovering the anatomical relationships between the vestibulo-auditory organs, in documenting the changes within the boney labyrinth with otologic and vestibular disease, and in evaluating the changes in the end organs after cochlear implantation. Each temporal bone histopathologic laboratory currently in activity has contributed new findings and new relationships to the field of otology/neurotology. Additionally, with the passage of time, each researcher becomes ever more aware of the clinical value of their previous findings and is able to identify those findings which in retrospect contributed most to the advancement of their field.
Contributors to this Research Topic of significant clinical contributions from temporal bone histopathology can organize and present their particularly effective findings. As opposed to their earlier significant contributions to the field, we ask that they use the benefit of 20/20 hindsight to identify the clinically impactful features of their previous work and present them anew with explicit attention to the advancement in our field which those studies enabled. Topics would include, but would not be limited to, the following:
• sensorineural hearing loss
• congenital malformations
• changes with chronic systemic disease
• cochlear and ganglion cell counts with various disease processes
• effects of cochlear implantation
• effects of vestibular implantation. Human studies are preferred but animal studies will be considered (if they are clinically relevant)
• Finally, we ask the contributors to explore which special features of temporal bone histopathology were particularly conducive to their study’s exploration.
Conflicts of interest: Dr. Gluth is on the medical advisory board for the Advanced Bionics (Cochlear Implant) Corporation. Additionally, Dr. Adams is on a scientific advisory board for the company Advanced Bionics.
These laboratories often contain material accumulated over decades. Specialists who have dedicated their careers to the processing and interpretation of these specimens can each recall special impactful studies which were dear to their hearts. We ask that the contributors use the benefit of 20/20 hindsight to identify the clinically impactful features of their previous work and present them anew with explicit attention to the advancement in our field which those studies enabled.
Each specialist has accumulated special teaching series in their careers. The lessons from these series, and their demonstration with histopictographs, and application to clinical practice would be highly instructive to the neurotologic community.
Temporal bone histopathology has been particularly effective in discovering the anatomical relationships between the vestibulo-auditory organs, in documenting the changes within the boney labyrinth with otologic and vestibular disease, and in evaluating the changes in the end organs after cochlear implantation. Each temporal bone histopathologic laboratory currently in activity has contributed new findings and new relationships to the field of otology/neurotology. Additionally, with the passage of time, each researcher becomes ever more aware of the clinical value of their previous findings and is able to identify those findings which in retrospect contributed most to the advancement of their field.
Contributors to this Research Topic of significant clinical contributions from temporal bone histopathology can organize and present their particularly effective findings. As opposed to their earlier significant contributions to the field, we ask that they use the benefit of 20/20 hindsight to identify the clinically impactful features of their previous work and present them anew with explicit attention to the advancement in our field which those studies enabled. Topics would include, but would not be limited to, the following:
• sensorineural hearing loss
• congenital malformations
• changes with chronic systemic disease
• cochlear and ganglion cell counts with various disease processes
• effects of cochlear implantation
• effects of vestibular implantation. Human studies are preferred but animal studies will be considered (if they are clinically relevant)
• Finally, we ask the contributors to explore which special features of temporal bone histopathology were particularly conducive to their study’s exploration.
Conflicts of interest: Dr. Gluth is on the medical advisory board for the Advanced Bionics (Cochlear Implant) Corporation. Additionally, Dr. Adams is on a scientific advisory board for the company Advanced Bionics.
Keywords: presbyscusis, aging, dementia, sensorineural hearing loss, cochlear implantation, temporal bone histopathology, labyrinthine, neuroepithelium
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
