About this Research Topic
Extracellular vesicles (EVs) can be released from various cells. There are mainly two different types of EVs: microvesicles (MVs, 120-1000 nm) and EXs (30-120 nm). EVs have been recognized as a novel way of cell-cell communication by transferring their carried information, such as proteins and nucleic acid (DNA, mRNA, miRNA). They are also considered as an important player in the tissue “microenvironment” and inter-organ communications, such as the heart to the brain, adipose tissue to the brain, gut to the brain, etc. The potential role of stem cell EXs in the brain “microenvironment” manifests in several aspects such as protection of brain cells (neurons, astrocyte, glia cells, and endothelial cells), maintenance of blood-brain barrier hemostasis, and tissue repair (angiogenesis and neurogenesis).
Therefore, the aim of this Research Topic is to understand the role of EVs in central nervous system diseases by mediating intercellular communications through conveying their carried molecular information, which will ultimately lead to novel biomarkers or therapeutic avenues for central nervous system diseases such as stroke (ischemic stroke, hemorrhagic stroke, subarachnoid hemorrhage), Parkinson's disease, Alzheimer's disease, etc.
In this Research Topic, we welcome the submission of articles that research, but are not limited to, the following areas that lead to understanding the mechanism and exploring the therapeutical avenues for the central nervous system diseases:
• Role EVs in mediating cell-cell communication in the central nervous system diseases
• EV-mediated inter-organ communications, such as brain with heart, brain with adipose tissue, etc
• Biomarker role of EVs in central nervous system diseases
• Extracellular vesicles-based therapeutic approaches in animal models or patients
• Translational studies
Therefore, the aim of this Research Topic is to understand the role of EVs in central nervous system diseases by mediating intercellular communications through conveying their carried molecular information, which will ultimately lead to novel biomarkers or therapeutic avenues for central nervous system diseases such as stroke (ischemic stroke, hemorrhagic stroke, subarachnoid hemorrhage), Parkinson's disease, Alzheimer's disease, etc.
In this Research Topic, we welcome the submission of articles that research, but are not limited to, the following areas that lead to understanding the mechanism and exploring the therapeutical avenues for the central nervous system diseases:
• Role EVs in mediating cell-cell communication in the central nervous system diseases
• EV-mediated inter-organ communications, such as brain with heart, brain with adipose tissue, etc
• Biomarker role of EVs in central nervous system diseases
• Extracellular vesicles-based therapeutic approaches in animal models or patients
• Translational studies
Keywords: Stroke, central nervous system, stem cells, microRNAs, extracellular vesicles, exercise, diabetes, hypertension, adipose tissue
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
