About this Research Topic
A drug is a substance that can alter the physiological function of our body but may also be a poison that cannot be used to treat a disease. If a drug is used for the treatment of a disease, it is called medicine. Medicine is administered to a patient in the form of a dosage form (tablet, capsule, injection, etc.). Generally, a drug does not possess suitable properties (solubility, solid-state, taste, stability, etc.) to make its dosage form. This makes it imperative to prepare a suitable active pharmaceutical ingredient (API) of the drug. An API is the final form of a drug (base, salt, isomer, prodrug, polymorph, co-crystals, etc.) that is used to prepare a dosage form. An inventive API is a novel, non-obvious, and industrially applicable API. When the inventive API is commercialized, it becomes an innovative API. Different APIs of a drug have different physicochemical, pharmacokinetic, and toxicity profiles. Therefore, it is important to study the chemistry of the API in medicinal chemistry.
Chemistry plays a vital role in the process of discovery and development of a pharmaceutical drug product, wherein a chemist is an integral part of this process. Chemists and scientists of relevant disciplines need to understand the process of pharmaceutical drug development to enable them to generate pharmaceutical inventions. This Research Topic will emphasize the chemistry (synthesis, physicochemical properties, chemical interactions, stability studies, and quality parameters) of inventive and innovative APIs (base, salt, isomer, prodrug, conjugates, polymorph, co-crystals, etc.) of a drug product. This Research Topic will give a boost to the scientists, especially university scientists to develop pharmaceutical inventions of the API/drug they are working on.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Discovery and development of an inventive/innovative API (base, salt, isomer, prodrug, conjugates, polymorph, co-crystals, etc.) along with its physicochemical characterization
• Pre-formulation studies and comparative analysis of different APIs (base, salt, isomer, prodrug, conjugates, polymorph, co-crystals, etc.) of a single drug
• Chemistry and perspective on the synthetic methods (patented/non-patented) of existing APIs/APIs in clinical development
• Chemistry based drug-drug, drug-excipients, and pharmacokinetic interactions of APIs
• Quality control of an API
Chemistry plays a vital role in the process of discovery and development of a pharmaceutical drug product, wherein a chemist is an integral part of this process. Chemists and scientists of relevant disciplines need to understand the process of pharmaceutical drug development to enable them to generate pharmaceutical inventions. This Research Topic will emphasize the chemistry (synthesis, physicochemical properties, chemical interactions, stability studies, and quality parameters) of inventive and innovative APIs (base, salt, isomer, prodrug, conjugates, polymorph, co-crystals, etc.) of a drug product. This Research Topic will give a boost to the scientists, especially university scientists to develop pharmaceutical inventions of the API/drug they are working on.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Discovery and development of an inventive/innovative API (base, salt, isomer, prodrug, conjugates, polymorph, co-crystals, etc.) along with its physicochemical characterization
• Pre-formulation studies and comparative analysis of different APIs (base, salt, isomer, prodrug, conjugates, polymorph, co-crystals, etc.) of a single drug
• Chemistry and perspective on the synthetic methods (patented/non-patented) of existing APIs/APIs in clinical development
• Chemistry based drug-drug, drug-excipients, and pharmacokinetic interactions of APIs
• Quality control of an API
Keywords: Drug discovery, API, Pharmaceutical development, Physicochemical interaction, Patent
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
