About this Research Topic
Discovery of reliable markers for prognosis and early diagnosis of diseases require the elucidation of the underlying mechanisms for disease pathogenesis, identification of associated risk factors, and subsequent evaluation of potential candidates. With the development of high-throughput sequencing technologies, a large number of disease-associated risk factors and/or signaling pathways have been identified. However, their translational potential is still limited as these risk factors/pathways need to be streamlined for therapeutic purposes and their underlying mechanisms require further investigation. This is in part due to the lack of appropriate in vivo and/or in vitro model system in a human context. Recent advances in three-dimensional culture systems, including neurosphere, organoid, and assembloid, together with humanized animal models, should facilitate the translation of potential disease markers for prognosis, diagnosis, and therapies of neurodevelopmental and neurodegenerative diseases.
We welcome original research articles, technical reports, and reviews covering topics related to advances in statistical genetics as well as in vivo and in vitro systems modeling neurodevelopmental and/or neurodegenerative diseases. We will gladly consider topics including but not limit to the following:
• Innovative methods for identifying and/or detection of early markers of diseases
• Advances in in vivo or in vitro systems modeling neurodevelopmental and/or neurodegenerative diseases
• Development of therapeutic strategies to improve the functions/survival of neurons
• Investigation of underlying mechanisms of disease pathogenesis
Keywords: Neurosphere, organoids, stem cell, 3D culture, gene expression, genetics, inherited retinal degeneration, Usher syndrome, animal models, dementia, autism, sleep disorder, depression, Parkinson’s disease, Joubert syndrome and related disorders, Alzheimer's disease, Hungtington’s disease
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