About this Research Topic

Background

Heart failure (HF) has been named “the growing epidemic.” Over the last decade, the annual number of HF hospitalizations has almost doubled with approximately 50% of patients being rehospitalized within 6 months of discharge. The complex array of physiologic, psychological, social, and health care delivery issues makes it a challenging chronic disease to manage. Understanding the epidemiology and pathophysiology of the syndrome, identifying the predictors and their strength of association with outcomes, and using the available diagnostic modalities cost-effectively are essential in order to implement novel therapeutic approaches to curb this epidemic.

The primary aim of this research topic is to develop a collection of articles highlighting innovative, current research in novel or emerging therapeutic approaches (conservative and invasive) in both acute and chronic settings of the disease. We also aim to highlight research on potential interactions and/or barriers with concomitant cardiovascular or non-cardiovascular diseases in HF.

In this Research Topic, we invite authors to contribute original research articles, as well as review articles that address such research and that also investigate why, despite the emergence of novel therapeutic approaches that promise life prolongation and hospital length reduction, this patient population will often have a poor prognosis and may often require rehospitalization.

Potential topics within this collection may include but are not limited to:
1) Targeting novel pathophysiologic pathways in HF.
2) Novel therapeutic interventions for HF which target the myocardium or the cytoskeleton.
3) Novel therapeutic targets and approaches to prevent progression of HF to advanced stages.
4) Emerging therapeutic approaches in HF with preserved ejection fraction.
5) The treatment of right-sided HF.
6) Management of acute and decompensated HF.
7) Pacemaker/cardiac resynchronization therapy.
8) Management of comorbidities in patients with chronic or acute HF.

Keywords: Heart Failure, Acute, Chronic, Novel Therapies, Emerging Therapies, Comorbidities, HFrEF, HFpEF, Therapeutics

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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