New Generation Nano-Biomaterials and their Potential Application in Drug Delivery and Bio-sensing

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Background

Nano-technological advancements made in the current era have revolutionized the perspective and direction of research in almost every field of science. Amongst all the possible heterogeneous applications of nanoscience in the current decade, the contribution made toward biomedical engineering is groundbreaking. To date, diverse novel nanomaterials have been developed and applied in biomedical applications such as drug delivery, gene therapy, anticancer and anti-microbial agent, disease diagnosis, etc. Out of all these possible applications, disease diagnosis and therapy are more challenging therefore, the development of new and novel nanomaterials would be a key aspect both for scientific innovation and the prosperity of society. Further, the dynamic properties of elements at the nanoscale level have invigorated the urge to design and engineer novel nanomaterials specifically involving inorganic-based nanomaterials, carbon-based nanomaterials, organic-based nanomaterials, composite-based nanomaterials. In the emerging era of biocybernetics, there is a growing demand for engineering biocompatible, non-immunogenic, stable implantable biochips and nanorobotics for monitoring multiple physiological and/or physicochemical parameters as well as disease diagnosis and treatment. In addition peptides, proteins and polymer-based soft materials have been identified as potential drug delivery vectors. Therefore, it can be roughly speculated that there awaits a brighter and marvelous future in the field and application of nanotechnology at and beyond the horizon where there is a thin line between practical and science-fiction. Again, it is also clear that evolution in scientific innovation is incomplete without imagination, thus the only limiting factor that drives the underlying breakthroughs in nanoscience is the ability of research to imagine and comprehend a scientific problem in a pragmatic manner.



The goal of the research is to develop novel nanomaterials for biomedical applications. Especially, to the development of protein/polymer/peptide-based nanomaterials such as nanoparticles, or nanostructure for the small molecule/ therapeutic siRNA/antisense oligonucleotide delivery. In addition, the development of metal-based nanoparticles is to use as potential biosensing tools for disease diagnosis. Besides, we are promoting to develop the new biomaterials such as carbon dots and quantum dots in the detection of disease macromolecules as fluorescence probes. The development of fluorescent quantum/carbon dots as molecular markers and environmental tracers and heavy metals will create cancer-like disease. We will assist in the identification of novel nanoparticles for biosensor applications in a variety of biomolecules, including therapeutic proteins, nucleic acids, lipids, carbohydrates, and small molecule detection. Nanomaterials could also be used to diagnose a variety of pathogenic organisms such as viruses, bacteria, and their component as antigens.



We welcome the submission of Original Research, Review, Mini Review, Perspective articles on various themes such as the following:

• Design and synthesis of peptide self-assembly for antisense oligo-nucleic acid or siRNA delivery.

• Development of new nanoparticles for biosensor application in biomaterials research.

• Development of polymer-based drug delivery system.

• Fluorescent nanoparticles/nanodots for bioimaging probe.

• QDs/CDs for antibiotics, hazardous materials tracing.

• Peptide generated metal nanoparticles and their small molecule delivery application.

• Mechanistic study on polymer/peptide-based nano delivery system.

• Stability study of polymer/peptide nanocarrier.

• Comparative gene knockdown study via nanocarrier.

• Polymer-based Nano hydrogel and its drug loading and slow-release application.

Keywords: Self-assembly, Nanocarriers, Drug Delivery, Nanoparticles, Biosensor, Semi-conductor photocatalysis, Hydrogels

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