About this Research Topic

Background

Age-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuroinflammation as well as neuronal degeneration. Apoptosis, necrosis, and autophagy are all types of programmed cell death that are morphologically distinct from one another. Over the last decade, extensive research has been conducted on necroptosis, resulting in a better understanding of its molecular underpinnings and role in neurodegenerative diseases. A later study investigates the processes of apoptosis and necroptosis, as well as their roles in the activation of
inflammatory immune responses. Although there is a distinct mode of cell death with distinct morphological characteristics, its identification and implications in neurological diseases are still unknown. Interestingly, emerging evidence has established a direct link between epigenetic and posttranslational modifications and neurodegenerative disease. Using epigenetic and proteomic methods, researchers uncovered genes and proteins that may play a function in the area of neuroinflammation, a role that has hitherto been overlooked. New pharmacological targets and therapeutic options for
neurodegenerative diseases are being investigated in order to gain a better understanding of the disease's origins and progression by using neuronal death and neuroinflammation models that are associated with epigenetic changes.

This research topic places a high value on research advances that are original, significant, and distinctive in their examination of the relationship between neuronal cell death mechanisms and microglia
activation that results in neuroinflammation and neurodegenerative diseases. We hope to gain a better understanding of the implications of programmed cell death in the future, as well as the molecular
mechanisms that underpin and influence such consequences, in order to help alleviate neurodegenerative diseases.

Submitted articles on a wide range of topics are encouraged, including but not limited to review articles, mini-review articles, and original research articles on:

1. Neuroinflammation and programmed cell death in neurodegenerative diseases such as Alzheimer's and Parkinson's disease, whether acute or chronic in nature.
2. Cross-talk between necroptosis, mitophagy, and autophagy involved in microglial neuroinflammation and neurodegenerative disease.
3. Apoptotic cell clearance mechanisms in neuroinflammatory and neurodegenerative autoimmune disorders including but not limited to multiple sclerosis
4. Bacterial pathogenesis, viral infection, and Gut Microbiota are all factors that can reactivate T cells and Dendritic cells, leading to neuroinflammation at the Gut-Brain and the Gut-Lung Axis.
5. Studies in epigenetics and proteomics, as well as new drug targets and therapeutic strategies for neurodegenerative diseases are being conducted to determine the precise cause of pathological
inflammation.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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