About this Research Topic

Background

Ketamine and its enantiomers (R, S) represent pharmacologically novel treatment avenues for individuals with treatment-resistant depression, exerting rapid and robust antidepressant and anti-suicidal effects that provide new hope to affected persons.

Frontiers in Psychiatry is working to promote integrative multidimensional psychiatry research through an interdisciplinary approach to mental health. This Research Topic on Ketamine aims to promote the collaboration of multidisciplinary teams from a variety of professional disciplines to foster high standards of comprehensive care, research, and best practice in psychiatry to attract high-quality original research papers, comprehensive review articles, and opinion papers. The shared implications of the studies will:

a) Provide an overview of recent advances in research on Ketamine and its enantiomers (R, S) with psychiatric disorders.
b) Help identify comprehensive intervention strategies to enhance mental health outcomes.
c) Expand awareness around the use of Ketamine and its enantiomers with multiple implications for psychiatric care and practice.

We welcome original research and review articles of both preclinical and clinical studies on but not limited to:

• The impact of Ketamine on suicidal symptoms in individuals with mood disorders
• The impact of Ketamine in adult and child populations with major depressive disorder (MDD)
• Ketamine in depression with psychotic symptoms
• Ketamine in bipolar depression, complex trauma, anxiety disorders, and personality disorders
• Ketamine as a long-term treatment: outcomes and adverse effects
• Case reports and/or case series regarding Ketamine administration in the clinical routine
• Outcome studies with the implementation of Ketamine assisted psychotherapy
• The administration of Ketamine beyond the diagnosis of MDD
• The neurobiological underpinnings of psychiatric treatment with Ketamine
• Ketamine-related novel treatments for depression

Keywords: Ketamine, Glutamate Modulation, Neuroplasticity, Depression, Suicidality, Antidepressant Treatment, Ketamine Assisted Psychotherapy

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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