Antiviral Innate Immune Sensing, Regulation, and Viral Immune Evasion

164.1K

views

391

authors

48

articles

Antiviral Innate Immune Sensing, Regulation, and Viral Immune Evasion

164.1K

views

391

authors

48

articles

Editorial

04 January 2024

Editorial: Antiviral innate immune sensing, regulation, and viral immune evasion

Wenting Lu

,

Ling Wang

and

Junji Xing

16,214 views

0 citations

Editors

4

McGill University

Houston Methodist Research Institute

Xuzhou Medical University

Henan Normal University

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About

The innate immune system is crucial to defend against viruses or other pathogenic microbes in the early phases of infection. The response starts with detecting evolutionarily conserved structures, termed pathogen-associated molecular patterns (PAMPs), by a set of germline-encoded pattern-recognition receptors (PRRs). Following the detection of specific viral PAMPs, PRRs trigger the activation of intracellular signaling cascades, ultimately leading to the induction of type I interferons (IFNs), pro-inflammatory cytokines, and antiviral genes through the activation of interferon regulatory factor 3 (IRF3) and IRF7.

Antiviral pathways need to be tightly regulated to ensure successful antiviral defenses and avoid aberrant or dysregulation of host immune signaling. We believe that the Research Topic will give updated insights into the dynamic fields of PAMPs sensing in antiviral innate immunity and viral immune evasion. We hope it will serve the purpose of encouraging new research. This Research Topic will provide an overall picture of antiviral innate immune sensing signal pathways, regulation, and viral immune evasion. We welcome the submission of Original Research, Review, Mini-Review, Hypothesis and Theory, and Perspective articles that cover, but are not limited to, the following subtopics:

1. Mechanisms of different PRRs and their downstream key adaptors to trigger early antiviral innate immunity

2. Mechanisms used by host cells to positively or negatively regulate antiviral innate immune sensing signal pathway

3. Viral immune evasion mechanisms by targeting immune sensors, adaptor molecules, intracellular kinases, and transcription factors

The innate immune system is crucial to defend against viruses or other pathogenic microbes in the early phases of infection. The response starts with detecting evolutionarily conserved structures, termed pathogen-associated molecular patterns (PAMPs), by a set of germline-encoded pattern-recognition receptors (PRRs). Following the detection of specific viral PAMPs, PRRs trigger the activation of intracellular signaling cascades, ultimately leading to the induction of type I interferons (IFNs), pro-inflammatory cytokines, and antiviral genes through the activation of interferon regulatory factor 3 (IRF3) and IRF7.

Antiviral pathways need to be tightly regulated to ensure successful antiviral defenses and avoid aberrant or dysregulation of host immune signaling. We believe that the Research Topic will give updated insights into the dynamic fields of PAMPs sensing in antiviral innate immunity and viral immune evasion. We hope it will serve the purpose of encouraging new research. This Research Topic will provide an overall picture of antiviral innate immune sensing signal pathways, regulation, and viral immune evasion. We welcome the submission of Original Research, Review, Mini-Review, Hypothesis and Theory, and Perspective articles that cover, but are not limited to, the following subtopics:

1. Mechanisms of different PRRs and their downstream key adaptors to trigger early antiviral innate immunity

2. Mechanisms used by host cells to positively or negatively regulate antiviral innate immune sensing signal pathway

3. Viral immune evasion mechanisms by targeting immune sensors, adaptor molecules, intracellular kinases, and transcription factors

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Editors

McGill University

Houston Methodist Research Institute

Xuzhou Medical University

Henan Normal University

Impact

164,141 Total views

108,620 Article views

51,499 Article downloads

4,022 Topic views

Published In

Frontiers in Immunology

Viral Immunology

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