High-Throughput Genome Sequencing Technologies, Methods, and their Applications

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ORIGINAL RESEARCH

Published on 07 Mar 2024

Proband-independent haplotyping based on NGS-based long-read sequencing for detecting pathogenic variant carrier status in preimplantation genetic testing for monogenic diseases

Peiyu Zhang
Xiaomei Zhao
Qinshan Li
Yaqiong Xu
Zengmei Cheng
Lu Yang
Houmei Wang
Yang Tao
Guanyou Huang
2 more
Shuyun Zhao

doi 10.3389/fmolb.2024.1329580

1,739 views
2 citations

ORIGINAL RESEARCH

Published on 09 Feb 2024

Analytical validation and clinical utilization of K-4CARE™: a comprehensive genomic profiling assay with personalized MRD detection

Thien-Phuc Nguyen Hoang
Tien Anh Nguyen
Nam H. B. Tran
Van-Anh Nguyen Hoang
Hong Thuy Thi Dao
Vu-Uyen Tran
Yen Nhi Nguyen
Anh Tuan Nguyen
Cam Tu Nguyen Thi
4 more
Lan N. Tu

doi 10.3389/fmolb.2024.1334808

2,291 views
2 citations

ORIGINAL RESEARCH

Published on 13 Dec 2023

Scalable noninvasive amplicon-based precision sequencing (SNAPseq) for genetic diagnosis and screening of β-thalassemia and sickle cell disease using a next-generation sequencing platform

Pragya Gupta
V. R. Arvinden
Priya Thakur
Rahul C. Bhoyar
Vinodh Saravanakumar
Narendra Varma Gottumukkala
Sangam Giri Goswami
Mehwish Nafiz
Aditya Ramdas Iyer
8 more
Sivaprakash Ramalingam

doi 10.3389/fmolb.2023.1244244

2,498 views
1 citation

HYPOTHESIS AND THEORY

Published on 29 Jun 2023

A non-mutated TROP2 fingerprint in cancer genetics

Emanuela Guerra
Roberta Di Pietro
Gianmarco Stati
Saverio Alberti

doi 10.3389/fonc.2023.1151090

2,052 views
3 citations

ORIGINAL RESEARCH

Published on 16 May 2023

Whole-genome sequencing of multidrug resistance Salmonella Typhi clinical strains isolated from Balochistan, Pakistan

Sareen Fatima
Zaara Ishaq
Muhammad Irfan
Abdullah F. AlAsmari
Jahangir Khan Achakzai
Tahreem Zaheer
Amjad Ali
Ali Akbar

doi 10.3389/fpubh.2023.1151805

3,968 views
6 citations

METHODS

Published on 28 Apr 2023

HOPE (SOLTI-1903) breast cancer study: real-world, patient-centric, clinical practice study to assess the impact of genomic data on next treatment decision-choice in patients with locally advanced or metastatic breast cancer

Rubén Olivera-Salguero
Elia Seguí
Juan Miguel Cejalvo
Mafalda Oliveira
Pablo Tolosa
Maria Vidal
Marcos Malumbres
Joaquín Gavilá
Cristina Saura
24 more
Tomás Pascual

doi 10.3389/fonc.2023.1151496

2,160 views
1 citation

ORIGINAL RESEARCH

Published on 16 Dec 2022

Identification and mechanistic basis of non-ACE2 blocking neutralizing antibodies from COVID-19 patients with deep RNA sequencing and molecular dynamics simulations

Alger M. Fredericks
Kyle W. East
Yuanjun Shi
Jinchan Liu
Federica Maschietto
Alfred Ayala
William G. Cioffi
Maya Cohen
William G. Fairbrother
6 more
Sean F. Monaghan

doi 10.3389/fmolb.2022.1080964

1,528 views
2 citations

ORIGINAL RESEARCH

Published on 07 Oct 2022

Comprehensive bioinformatics and machine learning analysis identify VCAN as a novel biomarker of hepatitis B virus-related liver fibrosis

Mengqin Yuan
Xue Hu
Lichao Yao
Pingji Liu
Yingan Jiang
Lanjuan Li

doi 10.3389/fmolb.2022.1010160

2,645 views
3 citations

ORIGINAL RESEARCH

Published on 21 Sep 2022

A comprehensive next generation sequencing tissue assay for Asian-prevalent cancers—Analytical validation and performance evaluation with clinical samples

Cedric Chuan-Young Ng
Sandy Lim
Abner Herbert Lim
Nur Diyana Md Nasir
Jingxian Zhang
Vikneswari Rajasegaran
Jing Yi Lee
Jessica Sook Ting Kok
Aye Aye Thike
7 more
Bin Tean Teh

doi 10.3389/fmolb.2022.963243

3,257 views
4 citations

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Articles

Proband-independent haplotyping based on NGS-based long-read sequencing for detecting pathogenic variant carrier status in preimplantation genetic testing for monogenic diseases

Analytical validation and clinical utilization of K-4CARE™: a comprehensive genomic profiling assay with personalized MRD detection

Scalable noninvasive amplicon-based precision sequencing (SNAPseq) for genetic diagnosis and screening of β-thalassemia and sickle cell disease using a next-generation sequencing platform

A non-mutated TROP2 fingerprint in cancer genetics

Whole-genome sequencing of multidrug resistance Salmonella Typhi clinical strains isolated from Balochistan, Pakistan

HOPE (SOLTI-1903) breast cancer study: real-world, patient-centric, clinical practice study to assess the impact of genomic data on next treatment decision-choice in patients with locally advanced or metastatic breast cancer

Identification and mechanistic basis of non-ACE2 blocking neutralizing antibodies from COVID-19 patients with deep RNA sequencing and molecular dynamics simulations

Comprehensive bioinformatics and machine learning analysis identify VCAN as a novel biomarker of hepatitis B virus-related liver fibrosis

A comprehensive next generation sequencing tissue assay for Asian-prevalent cancers—Analytical validation and performance evaluation with clinical samples

Frontiers in Molecular Biosciences

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