Pharmacokinetic Differences of Drugs and Their Regulatory Mechanisms Under Dual Status Including Normal and Diseased Organism

  • 14k

    Total Downloads

  • 50k

    Total Views and Downloads

Download PDFDownload EPUB

Submit your idea

You will be redirected to our submission process.

Submit your manuscript summarySubmit your manuscript

About this Research Topic

Submission closed

Background

Dual status refers to normal physiological state and abnormal disease state. In the process of new drug development, pharmacokinetic research has always played an important role from early screening and preclinical research to clinical research and post-marketing evaluation. However, preclinical pharmacokinetic data are mainly derived from healthy animals, which is unreasonable. On the one hand, patients are the final consumers of drugs because drugs are mainly used to treat patients with diseases. On the other hand, whether the body is in a pathological state and the severity of the disease have different effects on the absorption, distribution, metabolism, and excretion (ADME) of drugs, which is closely related to whether the clinical drug is safe and effective. Therefore, studying the pharmacokinetics in disease states is more meaningful and clinically relevant.

It's well known that the tissues and organs of the body will be damaged to different degrees in the disease state when compared with the normal state. For example, the metabolic function of the liver in patients with liver injury is reduced. The activity of metabolic enzymes in diabetic patients is changed. The type and quantity of intestinal flora in patients with rheumatoid arthritis are altered. The permeability of tract cells in patients with irritable bowel syndrome will be reduced. And the above changes have affected the pharmacokinetic process of the drug, thereby altering the bioavailability of the drug. In the process of disease occurrence and development, the intestinal flora and cell membrane permeability will not only be changed, but also the drug metabolizing enzymes and transporters related to drug metabolism and disposal are affected by abnormal regulation, and its possible mechanisms mainly involve inflammation-related signaling pathways/nuclear receptors, epigenetic modification and protein post-translational modification, etc., which result in changes in the pharmacokinetic behavior of drugs, drug efficacy, and toxicity. Therefore, we should pay more attention to the regulatory mechanisms that cause the pharmacokinetic differences of drugs in the dual status organism.

Given the fact that drugs are mainly used in the body under disease states, this topic focuses on pharmacokinetic differences of drugs and their regulatory mechanisms under dual status including normal and diseased organisms. We hope to optimize the drug evaluation system based on disease states, individualized safety provides reference and ideas for effective drug use. In this Research Topic, we welcome original research, reviews, and mini reviews articles, including but not limited to the following subjects:
•The pharmacokinetic differences of drug including Chinese medicine and their mechanisms under normal and disease status.
• The changes in the expression and function of drug-metabolizing enzymes and drug transporters in disease status and their related regulatory mechanisms.
•The study of intestinal microbiome mediated drug metabolism and its effect on drug efficacy and toxicity.
• ADME/toxicity of drugs as well as their regulation, drug-drug interactions mediated by nuclear receptors, transporters and metabolic enzymes based on the methods and techniques of pharmacokinetics, transcriptomics, and metabolomics.
• The study of drug pharmacokinetic-pharmacodynamic (PK-PD) link model under disease status.

Keywords: Dual status, Pharmacokinetic differences, Drug metabolizing enzymes, transporters, Nuclear receptors, Gut microbiota, Pharmacokinetic-pharmacodynamic link model

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

     

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

     

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

     

Impact

  • 50kTopic views
  • 34kArticle views
  • 14kArticle downloads
View impact