Information processing within different CNS regions is coordinated via a large diversity of local circuit and long-range projecting GABAergic neurons. Similar to traffic lights positioned at different crossroads, GABAergic neurons keep the operation of circuits in order allowing for complex brain computations associated with cognitive functions. Importantly, several decades of work highlighted the role of GABAergic neurons in several CNS pathologies, including neurodevelopmental and neurodegenerative disorders, such as autism, schizophrenia, Alzheimer’s disease, and ALS. By regulating network excitation/inhibition balance and inter-regional communication, GABAergic neurons appear to play a crucial role in circuit development, function, and dysfunction.
This Research Topic will be linked to the Symposium “GABAergic circuits in health and disease” held conjointly with the Annual Meeting of the Canadian Association for Neuroscience in May 2022; however, the Research Topic is open to all submissions across the globe, independently of the Symposium. We intend to highlight recent findings obtained by different laboratories working in the field of GABAergic circuits and to put forward new ideas that will foster further discoveries on organization, function, and dysfunction of GABAergic circuits.
The Topic will provide a comprehensive view on the structural and functional organization of GABAergic inhibition in complex cortical and spinal networks making a bridge to its function during different behavioral states and dysfunction in brain disorders. We invite all types of contributions to cover different topics within the GABAergic circuit theme, including circuit development, synaptic plasticity and interneuron-glia interactions, GABAergic cell diversity with a focus on long-range and disinhibitory circuit elements, role of GABAergic circuits in network activity during animal behavior and dysfunction in brain disorders such as epilepsy, autism, Alzheimer, and ALS.
Information processing within different CNS regions is coordinated via a large diversity of local circuit and long-range projecting GABAergic neurons. Similar to traffic lights positioned at different crossroads, GABAergic neurons keep the operation of circuits in order allowing for complex brain computations associated with cognitive functions. Importantly, several decades of work highlighted the role of GABAergic neurons in several CNS pathologies, including neurodevelopmental and neurodegenerative disorders, such as autism, schizophrenia, Alzheimer’s disease, and ALS. By regulating network excitation/inhibition balance and inter-regional communication, GABAergic neurons appear to play a crucial role in circuit development, function, and dysfunction.
This Research Topic will be linked to the Symposium “GABAergic circuits in health and disease” held conjointly with the Annual Meeting of the Canadian Association for Neuroscience in May 2022; however, the Research Topic is open to all submissions across the globe, independently of the Symposium. We intend to highlight recent findings obtained by different laboratories working in the field of GABAergic circuits and to put forward new ideas that will foster further discoveries on organization, function, and dysfunction of GABAergic circuits.
The Topic will provide a comprehensive view on the structural and functional organization of GABAergic inhibition in complex cortical and spinal networks making a bridge to its function during different behavioral states and dysfunction in brain disorders. We invite all types of contributions to cover different topics within the GABAergic circuit theme, including circuit development, synaptic plasticity and interneuron-glia interactions, GABAergic cell diversity with a focus on long-range and disinhibitory circuit elements, role of GABAergic circuits in network activity during animal behavior and dysfunction in brain disorders such as epilepsy, autism, Alzheimer, and ALS.