Practical recommendations and consensus for the management of immune mediated hematologic diseases

  • 9,799

    Total Downloads

  • 43k

    Total Views and Downloads

About this Research Topic

Submission closed

Background

In the last decade growing attention has been paid even to the so-called benign hematologic conditions, including immune mediated diseases. The latter encompass autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), autoimmune neutropenia (AIN), aplastic anemia (AA), and immune mediated disorders with thrombophilic or hemorragic symptoms (namely anti-phospholipid syndrome, thrombotic microangiopathies and acquired hemophilia). All these forms show a great clinical heterogeneity, ranging from mild easily manageable cases to life-threatening and fatal ones. Moreover, a plethora of novel laboratory tests and several new drugs are being developed and studied. Clinicians are therefore experiencing new challenges in the diagnosis and management of these diseases and practical recommendations and guidelines are lacking since available literature mainly relies on retrospective data often including small patient series. Furthermore, a deeper understanding of the immunologic mechanisms underlying the development of these rare and heterogeneous conditions will likely contribute to broaden the knowledge of disease pathogenesis in both primary and secondary forms and to develop novel target therapies.

In this special issue we will collect Experts’ opinions and recommendations regarding the diagnosis and management of immune mediated hematologic diseases. Furthermore, a focus on the mechanisms of immune mediated hematologic disease as well as an overview of hitherto underlying inborn errors of immunity will be presented. Particular attention will be paid to article dealing with the practical management of AIHA, ITP, AIN, AA, anti-phospholipid syndrome, thrombotic microangiopathies, acquired hemophilia. Specific settings, including the management of infectious or thrombotic complications, the workup of immune diseases secondary to tumors, primary immunodeficiencies, transplant or drugs, and the management of very rare clinical entities (i.e. Evans syndrome, moderate AA, large granular lymphocyte lymphoproliferative disorder etc.), will be explored. Furthermore, we will welcome manuscripts focusing on the immunologic mechanisms underlying immune mediated hematologic diseases and immunodeficiencies, including those dealing with novel markers of immune activation, insights in diseases pathogenesis, and predictors of response to therapy and outcome. All kind of manuscripts including expert opinions, consensus papers, literature reviews, and original articles with a focus on practical management of these diseases, as well as manuscripts dealing with old and new immunologic biomarkers, will be welcomed.

• Diagnosis and management of Evans’ syndrome (i.e. the association of AIHA, ITP, and/or AIN)
• Management of thrombotic and infectious risk in AIHA and ITP
• Diagnosis and management of hematologic disorders related to inborn errors of immunity
• Management of pregnancy in immune mediated hematologic conditions
• Management of AA (primary and secondary cases, moderate cases) and of AIN
• Diagnosis and management of autoimmune hemophilic and thrombophilic disorders
• Treatment choice in immune mediated hematologic conditions in the new drugs era and a focus on immunomodulatory properties of old and new drugs
• Immunological markers (like soluble mediators, molecular lesions, diseases associations etc) to be implemented in the understanding of diseases pathogenesis
• Immunological markers or techniques to be implemented in the diagnosis and management of immune mediated hematologic disorders
All types of articles will be accepted (see previous point), particularly original and research articles dealing addressing practical management and immunological mechanisms underlying the above mentioned conditions and expert consensus (i.e. Delphi surveys, etc.). If available, guidelines papers will also be welcomed.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.