Vascular Endothelial Niche: Endothelial Cells Mutually Interact With Neighboring and Circulating Cells in Complex Multicellular Networks or Vascular Niches

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About this Research Topic

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Background

Current research of vascular niche is a rapidly growing field in vascular biology. Endothelial cells, forming the inner wall of the blood vessels, participate in the body's pathological and physiological processes of immune, tumor, infection, etc. Endothelial cells do not only respond to the stimulation of external information, but they are also the decisive factors that act on neighboring tissues and circulating cells. Vascular endothelial niche was identified as the potentially rate-limiting factor for tumor metastasis. It is regulated by endovascular originated LRG1 (LRG1 can promote metastasis by increasing the number of prometastatic neural antigen 2). Also, the potential mechanism for the formation of vascular endothelial niche had been elucidated, as exosomal miR-25-3p was involved in pre-metastatic niche formation for colorectal cancer metastasis.

At present, more than 80% of the studies focused on the pre-metastatic niche formation for tumors including hematologic tumors. However, the research on vascular endothelial niches should not be limited to the tumor scope. This advanced concept should be explored in the research on physiological and pathophysiological processes in other diseases (such as diabetic retinopathy, hematopoiesis, lung alveolar development, sepsis, and aging diseases, etc.). It was not easy to explain clearly how the vascular niche interacted with neighboring tissues and cells. Therefore, more advanced methods like single-cell omics, gene knockout or conditional knockout mouse, or co-culture cell line system could be harnessed as a tool for explaining the interaction with neighboring cells.

Intervention with the vascular niche is meaningful in improving the treatment of some diseases. This Research Topic aims to encourage submissions, including original research, clinical studies, and review articles, that contribute innovative knowledge to further our understanding of the signaling and mechanisms of vascular endothelial niche in multiple diseases.
Potential topics keywords include but are not limited to the following:
• Animal, cellular, and molecular models of vascular endothelial niche response to nervous system disease/neuroinflammation
• Discovery of novel biomarkers and mechanisms related to the vascular endothelial niche
• Identification and pharmacological studies of vascular endothelial niche that target systemic inflammation-induced damage
• Signaling and mechanisms of tissue damage caused by vascular endothelial niche dysfunction
• Compounds that act on vascular endothelial niche dysfunction to alleviate systemic inflammation and organ injury
• Inhibition mechanism of vascular endothelial niche induced cell apoptosis, pyroptosis, and necrosis

Keywords: niche, endothelial cells, metastasis, exosome, pre-metastatic niche, nervous system disease, inflammation, neighboring tissues, circulating cells

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