About this Research Topic
Diabetic Neuropathy (DN) is a common complication of type 1 and type 2 diabetes. Diabetic peripheral neuropathy (DPN) and cardiac autonomic neuropathy (DCAN) lead to devastating complications like foot ulcers, lower limb amputations, major cardiovascular events and sudden deaths. It is estimated that up to 50% of people with diabetes may be affected by some type of neuropathy making it a significant cause of disability and reduction in quality of life. Complications related to both DPN and DCAN are preventable if detected early and risk factors are optimally controlled through multidisciplinary care.
At the heart of the effort to improve patient outcomes is efficient and accurate diagnosis. Due to the asymptomatic early stages of the disease progression, diagnosis is often a challenge. The issues are compounded by the threat of a point of irreversible disease development, if diagnosis is not made in a timely manner. This collection aims to address these challenges by featuring and discussing the latest advances and diagnostic approaches to diabetic neuropathy.
Furthermore, research has yet to reveal a definitive mechanism for the association between hyperglycaemia and nerve damage. With the pathogenesis unclear, treatment and prevention is limited. Therefore through this topic the disease pathogenesis will be explored with the aim of advancing preventative measures. More widely, to what degree can glycemic control reduce the onset and progression of diabetic neuropathy?
In this article collection we hope to highlight recent advances in research contributing to the diagnosis and prevention of diabetic neuropathy. We will accept both original research and reviews on the following, but not limited to:
• Screening methods to improve early detection of neuropathy in patients with diabetes
• Novel techniques for diagnosing DN and clinical applications
• Individual as well as population-level strategies to the prevention of DN
• Research aimed at understanding the mechanisms underlying DN progression
• Risk factors and biomarkers including glycemic control/glycemic variability predicting the progression of DPN
• Challenges in DPN management
At the heart of the effort to improve patient outcomes is efficient and accurate diagnosis. Due to the asymptomatic early stages of the disease progression, diagnosis is often a challenge. The issues are compounded by the threat of a point of irreversible disease development, if diagnosis is not made in a timely manner. This collection aims to address these challenges by featuring and discussing the latest advances and diagnostic approaches to diabetic neuropathy.
Furthermore, research has yet to reveal a definitive mechanism for the association between hyperglycaemia and nerve damage. With the pathogenesis unclear, treatment and prevention is limited. Therefore through this topic the disease pathogenesis will be explored with the aim of advancing preventative measures. More widely, to what degree can glycemic control reduce the onset and progression of diabetic neuropathy?
In this article collection we hope to highlight recent advances in research contributing to the diagnosis and prevention of diabetic neuropathy. We will accept both original research and reviews on the following, but not limited to:
• Screening methods to improve early detection of neuropathy in patients with diabetes
• Novel techniques for diagnosing DN and clinical applications
• Individual as well as population-level strategies to the prevention of DN
• Research aimed at understanding the mechanisms underlying DN progression
• Risk factors and biomarkers including glycemic control/glycemic variability predicting the progression of DPN
• Challenges in DPN management
Keywords: Diabetes, Diabetic peripheral neuropathy, cardiac autonomic neuropathy, Complications, Glycemic control, nerve damage, diagnosis, prevention
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
