Fish as Model Organism for Skeletal Diseases

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Background

The in-depth understanding of pathogenetic mechanisms of endocrine disorders, cannot be modeled in simple or cell-based systems. Consequently, in vivo studies are used to effectively model human experience; such experiments allow for potentially translational application in clinical contexts.

Whole-organism-based tools frequently recapitulate the physiological, behavioral, and molecular aspects of human diseases. Therefore, in vivo studies are used to discover and validate candidate genes and compounds that could culminate in novel therapeutic targets for bone diseases. Endocrinologists studying bone diseases often use rodent models with the benefit of short generation times and the possibility to replicate phenotypes and genotypes. Nevertheless, we are evidencing an increasing number of studies utilizing fish models (Zebrafish and Medaka) as faster and efficient alternative systems.

The need for translational results of in vivo experiments means that choosing the correct model organisms is of core importance. Furthermore, the application of human-relevant doses, testing at appropriate life-stages, and the use of appropriately susceptible species provide the most valuable results for application in human health. These tests aim for a comprehensive assessment of complex disorders lacking clear pathology, as well as the identification and/or prediction of endocrine-related disorders.

This Research Topic focuses on fish as model organisms in Bone Research, welcoming contributions demonstrating translational outcomes or barriers to these model organisms. The collection also seeks to identify relevant in vivo platforms for high-throughput studies in bone, functional studies, chemical screenings, and imaging technologies performed in fish, thus allowing their future implementation to the field of Bone Research.


Articles will be accepted pertaining to, but not limited to, the following:
- Fish model organisms for understanding bone diseases;
- Fish model organisms for understanding bone function;
-Chemical screening systems using fish for the identification of bone or cartilage modifiers
-Phenotypic screening systems in fish for the identification or validation of genes involved in complex human bone diseases

Keywords: fish, skeletal disease, in vivo studies, endocrinology, fish model

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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