Epidemiology of Epilepsy and Seizures

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About this Research Topic

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Background

Epilepsy is a serious chronic neurological disorder characterised by recurrent seizures. Over 80% of patients with epilepsy live in economically disadvantaged countries and predominantly under no treatment. Worldwide, it is estimated epilepsy affects 50 million people at any one time, and 4.8 million people have new onset epilepsy each year. Moreover, one in 26 people will develop epilepsy during their lifetime. Patients have repeated seizures that can lead to physical injuries and cumulative neuronal dysfunction. The indirect health impact of epilepsy extends beyond the brain, as patients have increased risk of cancer, and liver and vascular diseases. Patients with ongoing seizures cannot drive, and compared to people without epilepsy, have lower employment and productivity, and poorer quality of life.

In 2017, the International League Against Epilepsy has introduced new classifications of seizures and epilepsy. For better epilepsy management, it is crucial to improve our collective understanding on epidemiology of seizure and epilepsy.

Considering the numerous types of seizure and epilepsy and their healthcare burden, the research into the epidemiology of seizure and epilepsy is relatively limited. The goal of this Research Topic is to greatly extend our collective understanding on epidemiology of seizure and epilepsy in different population. Have better understanding of the prognosis of epilepsy and narrow the knowledge gap in long-term morbidity and mortality of epilepsy.

We are interested in original research articles, brief research, mini-reviews, full-length reviews, systematic reviews, perspective, opinions, hypothesis and theory generation that address following themes:

• Prevalence and incidence of epilepsy and seizure in adults
• Prognosis of epilepsy
• Treatment gap in epilepsy
• Long-term co-morbidity and mortality of epilepsy
• Prevalence and incidence of drug-resistant epilepsy
• Epidemiology of women with epilepsy
• Epidemiology of epilepsy and seizure in children and adolescents
• Epidemiology of acquired epilepsy, including post-traumatic, post-stroke, tumour-related epilepsy

Topic Editor Zhibin Chen received financial support from Early Career Fellowship. Topic Editor Patrick Kwan received financial support from Medical Research Future Fund Practitioner Fellowship. Martin J. Brodie received financial support from UCB, Eisai, Xenon, and Arvelle Therapeutics. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Keywords: Epilepsy; Seizure; Drug-resistant epilepsy; Adult; Children; Adolescence; Women; Post-stroke; Acute symptomatic seizures; Lennox-Gastaut Syndrome; Psychogenic non-epileptic seizures; Sudden unexpected death in epilepsy; Prevalence; Incidence; Mort

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