About this Research Topic

Background

Microbial infections are increasing day by day and costing many lives globally. The reported number of infections has now reached an alarming rate, mainly due to increasing incidences of antimicrobial resistance (AMR). Uncontrolled and irregular usage of antibiotics (especially during the COVID-19 pandemic) have caused substantial damage to healthcare systems and disease management. Therefore, we need new approaches that can address this global issue profoundly. Metabolomics has the power to unravel the metabolic effects of various antibiotics thus can help to identify novel drug targets to combat AMR. This Research Topic aims to help many researchers contribute their study focusing on the metabolic effects of various antibiotics in different bacterial infections.

This Research Topic aims to collect research articles with a focus on antibacterial drug resistance and its relationship with bacterial metabolism. Specially new updates and discoveries that show the role of metabolic reprogramming, identifying new druggable targets, and development of better strategies (drug combinations or metabolite supplementation) to combat drug resistance in bacterial pathogens. We welcome studies from all possible pathogenic bacterial research work.

Contributors are welcome to submit “original” research articles, review articles concerning the below mention (or similar) themes of this research topic:
• Effect of antimicrobial molecules on physiology and metabolism of bacteria.
• Effect of AMR on the bacterial metabolism.
• New target identification using metabolomics and genetic engineering to combat drug resistance.
• Using metabolomics to define the co-vulnerability of antibiotics and small molecule inhibitors.
• Characterizing new genes, pathways, drugs, inhibitors or any other small molecules that are affecting bacterial metabolism to enter into resistance or tolerance phase.
• Novel methods and techniques to study bacterial drug metabolism, drug interactions and combinations.
• Studies showing novel biotransformation of drugs or small molecules upon treatment.
• Metabolic effectors or suppressors affecting the drug efficacy or controlling resistance.

Keywords: Antimicrobial Resistance, AMR, Metabolism, Drug mechanism, Metabolic signatures, Metabolomics, Drug target

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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