About this Research Topic
The current research topic is committed to the publication of high-quality research and review articles which may shed light on novel and important mitochondria-based mechanisms and therapeutic interventions in neurodegenerative diseases, such as; Alzheimer's disease, Parkinson disease, Huntington disease, amyotrophic lateral syndrome etc. Earlier studies have established that mitochondria aging in the neurodegenerative brain is different from the healthy brain. The changes in mitochondria not only include structural and functional properties of the mitochondria but also in pathways to clear the impaired mitochondria from the diseased brain. Fruitful research in these aspects is not only vital in dissecting hidden yet important mitochondrial-based mechanisms, but also in discovery of potential therapeutics against neurodegenerative diseases. The interest will be focused on mitochondrial bioenergetics, mitochondrial autophagy, mitochondria apoptosis, and mitochondrial proteostasis in different cellular, ex vivo and in vivo models. Mitochondria genomic and proteomic profiling from subcellular components of the nervous system before and after drug intervention is also a subject of interest. The research on innovative methods of pure mitochondria isolation, bioenergetic and biochemical characterization from in vivo models will be considered for the collection. Innovative studies of mitochondria defects and effects of pharmacological drugs on novel neurodegenerative models will also be welcomed.
Studies related but limited to the following areas are of interest:
1. Essential role of new mitochondrial mechanisms in neurodegenerative diseases. Studies of mitochondria-based innovative bio-mechanisms covering mitochondria involvement in neurodegenerative disorders, for example, mitochondria autophagy, mitochondria apoptosis, faulty proteostasis, and defective bioenergetics.
2. In-silico and molecular drug effects in altering the functionality of brain and synapse mitochondria.
3. Novel models of neurodegenerative diseases characterizing alterations in structural and functional properties of mitochondria in different cell populations of the brain and nervous system.
4. Genomic and proteomic characterization of subcellular mitochondria in neurodegenerative models before and after drug administration.
5. New methods of pure mitochondria isolation including intensive molecular and biochemical characterization.
6. Pharmacological in-silico and molecular drug effects in altering the functionality of brain and synapse mitochondria.
The topic editors are happy to receive research articles, reviews and mini reviews, short communications, mini articles or research studies.
Studies related but limited to the following areas are of interest:
1. Essential role of new mitochondrial mechanisms in neurodegenerative diseases. Studies of mitochondria-based innovative bio-mechanisms covering mitochondria involvement in neurodegenerative disorders, for example, mitochondria autophagy, mitochondria apoptosis, faulty proteostasis, and defective bioenergetics.
2. In-silico and molecular drug effects in altering the functionality of brain and synapse mitochondria.
3. Novel models of neurodegenerative diseases characterizing alterations in structural and functional properties of mitochondria in different cell populations of the brain and nervous system.
4. Genomic and proteomic characterization of subcellular mitochondria in neurodegenerative models before and after drug administration.
5. New methods of pure mitochondria isolation including intensive molecular and biochemical characterization.
6. Pharmacological in-silico and molecular drug effects in altering the functionality of brain and synapse mitochondria.
The topic editors are happy to receive research articles, reviews and mini reviews, short communications, mini articles or research studies.
Keywords: Neurodegenerative diseases, Mitochondria autophagy, Mitochondria apoptosis, Faulty proteostasis, Defective bioenergetics, Mechanistic pathways
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
