About this Research Topic
T cell recognition of antigens depends on their processing and presentation by antigen presenting cells (APCs), which include dendritic cells, macrophages, and B cells. As important links between the innate and adaptive immune system, APCs can sense, integrate, and transmit information to T cells and other effector cells.
Central to this is the program of activation (sometimes termed maturation – not to be confused with differentiation from progenitors): Following exposure to external stimuli, such as pathogen-associated or damage-associated molecular patterns (PAMPS, DAMPS), cytokines, or cell surface receptor binding, APCs undergo phenotypic changes and acquire further effector functions. Depending on the nature of the stimulus, “activation” can encompass very distinct outcomes from induction of immunity or tolerance, and adequate APC activation is essential for initiating and maintaining effective immune responses.
There have been many advances in our understanding of APC activation in healthy tissues and its dysregulation in settings of infection, trauma or malignancy. However, many details are still unexplored. Furthermore, modern imaging techniques have enabled mapping tissue APCs with high spatial and temporal resolution, adding new layers of complexity to our understanding of their diversity and function.
The aim of this Research Topic is to give a fresh view on how different aspects of this fundamental feature of APC biology are regulated, and to examine immune regulation through the lens of APC function. Greater knowledge of mechanisms underlying APC function and diversity will enable better understanding of the induction of immunity, which may help future strategies for improving immunotherapy and vaccination.
This Research Topic welcomes submissions related to the spatial and temporal effects on DC cell activation and function, with manuscripts focusing on, but not limited to, the following specific topics:
1) Ubiquitination and Deubiquitination Regulation
2) Changing protein expression during activation
3) Differentially Regulated Gene Expression in various DC subsets
4) Organ-Specific subsets
5) Chemokine expression
6) Impaired DC antigen presentation in infection
Dr. Chae Gyu Park is an employee of Genuv Inc., involved in the development of therapeutics. The other Topic Editors declare no competing interests in relation to the Research Topic theme.
Central to this is the program of activation (sometimes termed maturation – not to be confused with differentiation from progenitors): Following exposure to external stimuli, such as pathogen-associated or damage-associated molecular patterns (PAMPS, DAMPS), cytokines, or cell surface receptor binding, APCs undergo phenotypic changes and acquire further effector functions. Depending on the nature of the stimulus, “activation” can encompass very distinct outcomes from induction of immunity or tolerance, and adequate APC activation is essential for initiating and maintaining effective immune responses.
There have been many advances in our understanding of APC activation in healthy tissues and its dysregulation in settings of infection, trauma or malignancy. However, many details are still unexplored. Furthermore, modern imaging techniques have enabled mapping tissue APCs with high spatial and temporal resolution, adding new layers of complexity to our understanding of their diversity and function.
The aim of this Research Topic is to give a fresh view on how different aspects of this fundamental feature of APC biology are regulated, and to examine immune regulation through the lens of APC function. Greater knowledge of mechanisms underlying APC function and diversity will enable better understanding of the induction of immunity, which may help future strategies for improving immunotherapy and vaccination.
This Research Topic welcomes submissions related to the spatial and temporal effects on DC cell activation and function, with manuscripts focusing on, but not limited to, the following specific topics:
1) Ubiquitination and Deubiquitination Regulation
2) Changing protein expression during activation
3) Differentially Regulated Gene Expression in various DC subsets
4) Organ-Specific subsets
5) Chemokine expression
6) Impaired DC antigen presentation in infection
Dr. Chae Gyu Park is an employee of Genuv Inc., involved in the development of therapeutics. The other Topic Editors declare no competing interests in relation to the Research Topic theme.
Keywords: antigen presentation, dendritic cells, B cells, macrophages, ubiquitination, cytokines, chemokines
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