About this Research Topic
Integral membrane proteins of Ion channels assemble to modulate the flow of ions into and out of a cell or intracellular organelle, leading to generation of electrical or chemical signals and regulating ion homeostasis. The abundance of ion channels in the plasma and intracellular membranes are subject to physiological and pathological regulations. Abnormal expressions of many ion channels in cancer have been observed and described. In the present issue, different ion channel distribution in cancer cells will be summarized. Pathophysiological implications related to ion channel distribution as well as functions will be highlighted.
This special issue focuses on distribution and functional aspects of ion channels in cancer, including;
- Ion channel distribution in cancer cells
- Ion channels and their effects on tumor microenvironment
- Ion channels and their influence on cancer pain
- Ion channel implications on cancer metabolism
- Ion channel and calcium signaling in cancer
- Ion channels and ion homeostasis in cancer
- Ion channels and cancer drug resistance
- Ion channels as a potential cancer therapeutic and chemotherapeutic drug target
Important Note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology
Keywords: marker, microenvironment, ion fluctuation, calcium signaling, ion channel proteins
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.