About this Research Topic
Present the problem that you would like to tackle in this Research topic and what can be done to achieve it including recent advances.
The aim of this Research Topic is to improve our understanding of Th17 and Treg cell dysregulation in autoimmunity. A better knowledge of Treg cell subsets and of their plasticity, is required to decipher their contribution to uncontrolled autoimmune responses. Moreover, Th17 cells can develop a pathogenic or immune tolerant phenotype. The plasticity and function of these T cell subsets are regulated by a variety of environmental and metabolic factors. Articles that are part of this collection will provide new insights into these regulatory mechanisms.
We welcome the submission of Original Research, Review and Mini-review articles that improve our understanding of Th17 and Treg cell dysregulation in autoimmune diseases. Topic areas of interest include, but are not limited to:
1. Molecular mechanisms that regulate the function, stability and plasticity of Treg cells and Th17 cells in health and autoimmune diseases
2. Environmental factors that modulate the balance between Treg cells and Th17 cells
3. New surface markers and transcription factors that help identifying different subpopulations of Treg cells in autoimmune diseases
4. Changes in the JAK/STAT signaling pathways and their implication in Th17 cell differentiation
5. Expansion of Treg cell populations as an experimental therapeutic approach to control autoimmune diseases
6. Molecular mechanisms regulating Treg cell and effector T cell migration into inflamed tissues
Keywords: Autoimmunity, inflammation, Treg, Th17, immunoregulation, environment, cytokines
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.