About this Research Topic
Fluorides are compounds that can be found in different natural and anthropogenic sources.
Their intake is associated with the prevention of dental decay and increased enamel and bone remineralization at a systemic level when consuming optimal levels (0.5-1.0 mg/L). Thus, topical and systemic use of these compounds has been researched.
When topically applied, fluoride has been employed in the management of dental and gingival alterations and associated with diverse treatments. Despite the reported benefits of adequate fluoride use, health damage can occur when permissible levels are chronically exceeded (>1.5 mg/L), in which systemic (skeletal fluorosis, damage in organs and systems) and dental alterations occur. The latter is highly relevant, since the clinical manifestation (dental fluorosis) constitutes a structural alteration associated with underlying systemic damage.
The severity of the disease can be identified by the characteristics of the tooth surface, through different indices: the Thylstrup & Fejerskov index (TFI) and Dean’s Index (DI) being the most employed. It is important to highlight that fluoride intake from drinking water for human consumption, food, mouth rinses, and dentifrices are considered the main sources for the development of dental and systemic fluorosis, which is recognized as a disabling disease that affects millions of people in distinct countries mainly in Africa, America, and Asia, with a significant socioeconomic and public health impact.
It is important to consider that fluoride exposure has repercussions at genetic, molecular, and cellular levels. Recent studies performed in exposed populations have focused on these characteristics, providing relevant advances regarding the pathogenesis of the disease.
This Research Topic will welcome manuscripts that provide novel and updated information in relation to:
• Fluoride exposure and oral health
• Clinical characteristics in association with epidemiological indices
• Case reports
• Habits of fluoride consumption and exposure
• Relationship between disease with mental health and cognitive impairment
• Genetic, molecular, and cellular studies related to genotypic characteristics of exposed populations
• Molecular analyses in association with susceptibility of the disease
• Molecular analyses in association to protection from the disease
• Environmental analyses in association with the disease
• Occupational analyses in association with the disease
• Behavior of the disease in vulnerable groups
• Prevalence and incidence analyses in exposed populations
• Preventive strategies against fluorosis development
• Socioeconomic impact of the disease
The Research Topic will be open (but not limited) to the following types of manuscript:
• Original research
• Epidemiological studies
• Review articles
• Case reports
• Clinical trials
We would like to acknowledge Dr. Omar Tremillo-Maldonado, Dr. Jesús Lavalle-Carrasco, and Dr. Sergio Manuel Salas-Pacheco who acted as coordinators and contributed to the preparation of the proposal for this Research Topic.
Their intake is associated with the prevention of dental decay and increased enamel and bone remineralization at a systemic level when consuming optimal levels (0.5-1.0 mg/L). Thus, topical and systemic use of these compounds has been researched.
When topically applied, fluoride has been employed in the management of dental and gingival alterations and associated with diverse treatments. Despite the reported benefits of adequate fluoride use, health damage can occur when permissible levels are chronically exceeded (>1.5 mg/L), in which systemic (skeletal fluorosis, damage in organs and systems) and dental alterations occur. The latter is highly relevant, since the clinical manifestation (dental fluorosis) constitutes a structural alteration associated with underlying systemic damage.
The severity of the disease can be identified by the characteristics of the tooth surface, through different indices: the Thylstrup & Fejerskov index (TFI) and Dean’s Index (DI) being the most employed. It is important to highlight that fluoride intake from drinking water for human consumption, food, mouth rinses, and dentifrices are considered the main sources for the development of dental and systemic fluorosis, which is recognized as a disabling disease that affects millions of people in distinct countries mainly in Africa, America, and Asia, with a significant socioeconomic and public health impact.
It is important to consider that fluoride exposure has repercussions at genetic, molecular, and cellular levels. Recent studies performed in exposed populations have focused on these characteristics, providing relevant advances regarding the pathogenesis of the disease.
This Research Topic will welcome manuscripts that provide novel and updated information in relation to:
• Fluoride exposure and oral health
• Clinical characteristics in association with epidemiological indices
• Case reports
• Habits of fluoride consumption and exposure
• Relationship between disease with mental health and cognitive impairment
• Genetic, molecular, and cellular studies related to genotypic characteristics of exposed populations
• Molecular analyses in association with susceptibility of the disease
• Molecular analyses in association to protection from the disease
• Environmental analyses in association with the disease
• Occupational analyses in association with the disease
• Behavior of the disease in vulnerable groups
• Prevalence and incidence analyses in exposed populations
• Preventive strategies against fluorosis development
• Socioeconomic impact of the disease
The Research Topic will be open (but not limited) to the following types of manuscript:
• Original research
• Epidemiological studies
• Review articles
• Case reports
• Clinical trials
We would like to acknowledge Dr. Omar Tremillo-Maldonado, Dr. Jesús Lavalle-Carrasco, and Dr. Sergio Manuel Salas-Pacheco who acted as coordinators and contributed to the preparation of the proposal for this Research Topic.
Keywords: fluoride exposure, preventive management, molecular analysis, genetic analysis, toxicity, fluorosis, epidemiology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
