About this Research Topic
This Research Topic will focus on the following themes:
1) ACE2 and TMPRSS2 expression in musculoskeletal tissues and cells
2) systemic inflammation role in bone and joint tissue physiology in patients with COVID-19
3) potential link between COVID-19 severity and musculoskeletal tissue damage
4) epidemiological data and molecular modeling and biochemical signaling studies able to identify musculoskeletal targets of COVID-19 infection
5) roles of COVID-19 therapies on musculoskeletal systems (e.g., corticosteroid and immunotherapies)
6) and COVID-19 long-term consequences on musculoskeletal systems
In this Research Topic, we welcome Original Research, Review, and Perspective articles on short-term and long-term musculoskeletal consequences in patients with mild-to-severe COVID-19 infection. Manuscripts submitted in this Research Topic should include, but not be limited to:
• ACE2 and TMPRSS2 and other human proteases related to COVID-19, e.g., furin, cathepsin L and B, elastase, trypsin and factor X, expression in musculoskeletal tissue;
• Role of systemic inflammation in bone and joint tissue physiology in patients with COVID-19, e.g. IL-1beta, IL-6, CXCL10, IL-17, TNF-alpha;
• Link between COVID-19 severity, comorbidity, age and aging, gender and musculoskeletal damage;
• epidemiological data and molecular modeling and biochemical signaling studies that identify musculoskeletal targets of COVID-19;
• Adverse effects of specific COVID-19 therapies on musculoskeletal systems;
• Post-COVID-19 syndrome (persistent symptoms at the post-viral stage of the disease) in musculoskeletal system.
With this Research Topic, we hope to promote greater insight into the potential relationship between COVID-19 and the musculoskeletal system.
Keywords: musculoskeletal system, COVID-19, SARS-COV-2, clinical presentation, symptoms, long-term consequences
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.