About this Research Topic
Within the process of hemostasis, platelet plug formation and its subsequent consolidation by fibrin is crucial in assuring a proper sealing of the damaged vessel wall and in cessation of bleeding. However, there is great variation in clot composition and structure, with as most striking example the comparison of venous vs. arterial clots. Over the last decade, more and more knowledge has been gained on clot build-up and composition, identifying different regions and concentration gradients of important platelet agonists within thrombi. This has been shown to be highly affected in several pathophysiological conditions. Also, the density and structure of the fibrin network is highly influenced by different physiological and pathophysiological conditions.
These insights into clot composition have been gathered using a plethora of in vitro and in vivo experimental systems modelling thrombus and fibrin formation combined with histological analyses of human thrombi collected by thrombectomy. Further, computational in silico modelling contribute progressively to our understanding of thrombus formation and build-up. Despite the great number of experimental tools and data available, the unexplained thrombotic complications seen in patients are still substantial. Hence, expanding our understanding of clot composition and structure in physiological and pathophysiological conditions will aid in the development and improvement of current and new antithrombotic treatments with limited hemorrhagic complications.
Topics may include, but are not limited to the assessment of:
1) Thrombus build-up and fibrin network structure.
2) Influence of genetic deficiency or acquired platelet or fibrin defects on clot properties.
3) The comparison and suitability of in vitro, in vivo and in silico research methods and novel advances within the field.
We welcome the submission of original articles, reviews, hypotheses/theory articles, method and protocol papers.
These insights into clot composition have been gathered using a plethora of in vitro and in vivo experimental systems modelling thrombus and fibrin formation combined with histological analyses of human thrombi collected by thrombectomy. Further, computational in silico modelling contribute progressively to our understanding of thrombus formation and build-up. Despite the great number of experimental tools and data available, the unexplained thrombotic complications seen in patients are still substantial. Hence, expanding our understanding of clot composition and structure in physiological and pathophysiological conditions will aid in the development and improvement of current and new antithrombotic treatments with limited hemorrhagic complications.
Topics may include, but are not limited to the assessment of:
1) Thrombus build-up and fibrin network structure.
2) Influence of genetic deficiency or acquired platelet or fibrin defects on clot properties.
3) The comparison and suitability of in vitro, in vivo and in silico research methods and novel advances within the field.
We welcome the submission of original articles, reviews, hypotheses/theory articles, method and protocol papers.
Keywords: Thrombus formation, clot structure, platelets, fibrin, microfluidics, in vivo thrombosis models, in silico modelling
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
