Adipose, skeletal muscle, intestine, bone and liver are the main metabolic organs that could produce respective organokines and cooperate together to maintain systemic metabolic homeostasis by the endocrine, paracrine, and autocrine manners. Novel identified adipokines zinc-alpha2-glycoprotein, hepatokines angptl8, and myokines irisin have been reported that play crucial roles in the regulation of glucose and lipid homeostasis. Several biological organokines are packaged into exosomes and then transported into specific organs to regulate local metabolism. Recent studies have confirmed that exosomal miRNA or protein as mediators of crosstalk of adipose-liver or liver-gut are involved in the occurrence and progression of obesity and related metabolic disease. Increasing numbers of exosomal miRNA have also been used as metabolic disease biomarkers in clinical settings. The field of exosomes and organokines biology and metabolism is rapidly expanding. Therefore, future research aiming to clarify the roles and mechanisms of exosomes or organokines in metabolic disease, will expand our understanding of inter-organ communication and accelerates the development of therapeutic approaches for metabolic diseases.
This Research Topic aims to:
1) provide insight into the roles and mechanisms of exosomes in the regulation of glucose lipid metabolism or inflammation
2) identify novel organokines or exosomal miRNAs that involved in the occurrence and progression of obesity and related metabolic disease
3) discover the specific biological markers of metabolic diseases in human populations from the perspective of exosomes or organokines.
This Research Topic welcomes Original Research and Review Articles focusing on, but not restricted to the factors in the regulation of obesity, NAFLD or related metabolic diseases including 1) Hepatokines, 2) Adipokines, 3) Myokines, 4) intestinal hormones, 5) bone-secreted factors, 6) exosomal miRNAs, protein, or lipids as well as clinical studies on the relationship between organokines or exosomes with metabolic disease.
Adipose, skeletal muscle, intestine, bone and liver are the main metabolic organs that could produce respective organokines and cooperate together to maintain systemic metabolic homeostasis by the endocrine, paracrine, and autocrine manners. Novel identified adipokines zinc-alpha2-glycoprotein, hepatokines angptl8, and myokines irisin have been reported that play crucial roles in the regulation of glucose and lipid homeostasis. Several biological organokines are packaged into exosomes and then transported into specific organs to regulate local metabolism. Recent studies have confirmed that exosomal miRNA or protein as mediators of crosstalk of adipose-liver or liver-gut are involved in the occurrence and progression of obesity and related metabolic disease. Increasing numbers of exosomal miRNA have also been used as metabolic disease biomarkers in clinical settings. The field of exosomes and organokines biology and metabolism is rapidly expanding. Therefore, future research aiming to clarify the roles and mechanisms of exosomes or organokines in metabolic disease, will expand our understanding of inter-organ communication and accelerates the development of therapeutic approaches for metabolic diseases.
This Research Topic aims to:
1) provide insight into the roles and mechanisms of exosomes in the regulation of glucose lipid metabolism or inflammation
2) identify novel organokines or exosomal miRNAs that involved in the occurrence and progression of obesity and related metabolic disease
3) discover the specific biological markers of metabolic diseases in human populations from the perspective of exosomes or organokines.
This Research Topic welcomes Original Research and Review Articles focusing on, but not restricted to the factors in the regulation of obesity, NAFLD or related metabolic diseases including 1) Hepatokines, 2) Adipokines, 3) Myokines, 4) intestinal hormones, 5) bone-secreted factors, 6) exosomal miRNAs, protein, or lipids as well as clinical studies on the relationship between organokines or exosomes with metabolic disease.