Antimicrobial resistance is a critical public health problem. The growing emergence of antibiotic-resistant bacteria and multidrug-resistant bacteria can be attributed to the misuse of antibiotics and the absence of effective antibiotics on the market. Antimicrobial resistance is a trouble that affects both human and veterinary medicine. This problem has led to a "One Health" approach to coordinate efforts and slow the development of drug-resistant microorganisms. In veterinary medicine, antibiotics are used to treat clinical infections and, in some countries, also as antimicrobial growth promoters. Antibiotic resistance in the veterinary field has led to limiting use to specific antimicrobials for human health, making the development of alternatives for the production of animal feed fundamental. Therefore, the primary challenge to antibiotic resistance has become the research and development of alternatives to traditional antibiotics.
It is necessary to research new antibacterial compounds and new strategies to fight bacterial infections. In the research for alternative therapies, essential oils (EOs), bacteriocins or antimicrobial peptides (AMPs) have been shown to be effective against a wide range of bacterial species, including multidrug-resistant bacteria. The increase in antimicrobial resistance and the antibiotic crisis has extended research into the potential use of EOs, bacteriocins and AMPs in the biomedical field for the prevention or treatment of infectious diseases. Furthermore, these compounds can be applied in all fields related to veterinary practice, has proven to be useful in the control of food-borne pathogens in animal-derived food (preventive), as well as in the potential clinical therapeutic use to fight infections in animal species. The combination of these substances of natural origin and antibiotic therapy can reduce antibiotic resistance spread.
This research topic aims to compile a collection of relevant articles (
See Article Types here ) that provide new insights into new treatment strategies for antibiotic-resistant and multidrug-resistant bacteria. Also, the combination of alternative substances of natural origin (EOs, bacteriocins and AMPs) and antibiotics has been recognized as a strategy to improve the therapeutic effect and limit the development of antibiotic resistance. The specific topics of the research topic are including, but not limited to:
• Relevance of alternative antibacterial strategies in antibiotic-resistant and multidrug-resistant bacterial infections in the clinical and veterinary field.
• "One Health" approach to slow the development of microorganisms resistance in human and veterinary medicine.
• Development of alternative antimicrobials of different origins and study of their structure, function and mode of action.
• Combination between alternative antimicrobials and antibiotics, as a possible strategy to limit antibiotic-resistant and multidrug-resistant bacterial infections.
Antimicrobial resistance is a critical public health problem. The growing emergence of antibiotic-resistant bacteria and multidrug-resistant bacteria can be attributed to the misuse of antibiotics and the absence of effective antibiotics on the market. Antimicrobial resistance is a trouble that affects both human and veterinary medicine. This problem has led to a "One Health" approach to coordinate efforts and slow the development of drug-resistant microorganisms. In veterinary medicine, antibiotics are used to treat clinical infections and, in some countries, also as antimicrobial growth promoters. Antibiotic resistance in the veterinary field has led to limiting use to specific antimicrobials for human health, making the development of alternatives for the production of animal feed fundamental. Therefore, the primary challenge to antibiotic resistance has become the research and development of alternatives to traditional antibiotics.
It is necessary to research new antibacterial compounds and new strategies to fight bacterial infections. In the research for alternative therapies, essential oils (EOs), bacteriocins or antimicrobial peptides (AMPs) have been shown to be effective against a wide range of bacterial species, including multidrug-resistant bacteria. The increase in antimicrobial resistance and the antibiotic crisis has extended research into the potential use of EOs, bacteriocins and AMPs in the biomedical field for the prevention or treatment of infectious diseases. Furthermore, these compounds can be applied in all fields related to veterinary practice, has proven to be useful in the control of food-borne pathogens in animal-derived food (preventive), as well as in the potential clinical therapeutic use to fight infections in animal species. The combination of these substances of natural origin and antibiotic therapy can reduce antibiotic resistance spread.
This research topic aims to compile a collection of relevant articles (
See Article Types here ) that provide new insights into new treatment strategies for antibiotic-resistant and multidrug-resistant bacteria. Also, the combination of alternative substances of natural origin (EOs, bacteriocins and AMPs) and antibiotics has been recognized as a strategy to improve the therapeutic effect and limit the development of antibiotic resistance. The specific topics of the research topic are including, but not limited to:
• Relevance of alternative antibacterial strategies in antibiotic-resistant and multidrug-resistant bacterial infections in the clinical and veterinary field.
• "One Health" approach to slow the development of microorganisms resistance in human and veterinary medicine.
• Development of alternative antimicrobials of different origins and study of their structure, function and mode of action.
• Combination between alternative antimicrobials and antibiotics, as a possible strategy to limit antibiotic-resistant and multidrug-resistant bacterial infections.