Dysregulation of Innate Immunity in Inflammatory Skin Disorders

Inflammatory skin disorders consist of a spectrum of cutaneous diseases like atopic dermatitis (AD) and psoriasis. They are mainly mediated by aberrant immune responses classified as type 1, type 2, and/or type 3. Major advances in the understanding of the pathogenesis of these diseases have shed new light on how innate immune responses critically regulate cutaneous inflammation. For instance, discoveries that group 2 innate lymphoid cells (ILC2s) promote AD-associated inflammation break through the theory that skin inflammation is merely dependent on adaptive immunity. Beyond ILCs, other innate immune cells participating in various skin disorders include granulocytes, antigen-presenting cells, and mast cells. Emerging evidence has demonstrated that the dysregulation of innate immunity may not only lead to devastating skin inflammation but also affects other functions like barrier intactness and somatosensation. More importantly, advanced biologic medications have been studied with those exciting findings in immunology. Thus, we believe that with the progress in immunology and medicine, more advanced medications that modulate innate immunity will be successfully developed for inflammatory skin diseases.

This Research Topic aims to understand the role of various innate immune cells in skin biology and function, as well as disease pathogenesis. Particularly, advanced findings of immune heterogeneity may provide new evidence to precisely classify specific diseases and study individualized therapies. Furthermore, interactions formed by immune cells and the nervous system or keratinocytes will provide a more comprehensive understanding of barrier immunology and neuroimmunology. The ultimate goal of this Research Topic is to answer how innate immunity influences itself, adaptive immunity, and other relevant tissues in the specific pathological context of the skin barrier.

Under this Research Topic, we will focus on innate immunity and its impact on skin biology. We aim to present Original Research, Review, and Perspective articles that may cover any of the following aspects:
• Novel roles of innate immune cells in skin inflammatory diseases like AD and psoriasis
• Innate immune cell interactions with the peripheral nervous system or epithelium and the effect of such crosstalk in the setting of skin diseases
• The heterogeneity of innate immune cells in dermatitis
• Molecular pathways derived from innate immunity in skin inflammation
• Translational potentials of novel scientific findings on innate immunity or evidence-based medicine in the context of skin disorders