About this Research Topic
In this Research Topic, our goal is to review the roles of memory Th2 cells in the pathogenesis of allergy highlighting homeostasis, the contribution of allergen-specific memory Th2 subsets in disease, and the underlying molecular mechanisms which maintain their potentially distinct homeostasis. Additionally, we will highlight the intrinsic factors essential for the development, homeostasis, tissue residency of memory T cells e.g., transcription factors, homeostatic cytokines, and the microenvironment in the allergic and healthy lungs. The differences in the homeostasis between Th2 and other Th cells or innate cells in the lung will also be addressed. Overall, the goal is to determine how function and homeostasis can be regulated for the treatment of allergic patients.
We welcome the submission of Original Research, Review, and Mini Review articles covering, but not limited to, the following sub-topics:
• Subsets of memory Th2 cells in the lung
• Intrinsic factors including transcription factors important for the development, homeostasis, and tissue residency of memory Th2 cells.
• Comparison of microenvironments between allergic and healthy lungs and influences on the homeostasis of memory Th2 cells.
• Homeostasis of memory Th2 cells compared with other memory Th cells or innate cells
• Therapeutic targets of memory T cells to treat allergic patients
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.