About this Research Topic
A significant challenge for researchers is delineating the specific contributions of discrete brainstem nodes, pathways, and transmitter systems to behavioral state and motor regulation. This is in large part due to the anatomically complex and highly cellular heterogeneous nature of the brainstem. Recent technological developments, including inducible knockouts mouse models and optogenetic and pharmacogenetic tools, are expected to significantly advance our understanding of the role(s) of brainstem circuits in regulating behavioral state and motor function, in both normal and pathophysiologic contexts.
This Research Topic encompasses the brainstem neural circuitry subserving behavioral state regulation, including wakefulness and motor behavior, NREM sleep, and REM sleep. This Research Topic will also explore the mechanisms by which brainstem diseases and disorders alter these behavioral states. We welcome contributions ranging from original research reports, technical or methods articles, reviews, and commentary or theoretical articles. We in addition seek papers describing new approaches and tools for elucidating brainstem structure-function relationships at the circuit level, in particular in the context of behavioral state regulation. This Research Topic's scope includes, but is not limited to, neuroanatomy, neurophysiology, molecular biology, neuropharmacology, functional neuroimaging, and disease states afflicting the brainstem.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.