About this Research Topic
In recent years, the study of lipid and iron metabolism in ferroptosis has attracted much attention, and it has gradually become a research hotspot in the fields of tumor metabolism. Ferroptosis was first proposed in 2012 by Brent R. Stockwell and colleagues as a distinct mode of programmed cell death. Since then, the underlying molecular and cellular mechanisms have evolved as a growing subject of in-depth research. Disturbances of ferroptosis may lead to a broad variety of pathologies, and targeting ferroptosis is already the subject of clinical trials. Importantly, the role of ferroptosis has been realized not only for the pathogenesis but also for the treatment of cancer.
Lipid and iron metabolism are central in ferroptosis. Their pathways are closely interrelated and play important roles in a variety of physiological and pathological processes leading to and governed by ferroptosis, and they are closely related to the occurrence and development of tumors. Targeting ferroptosis will open up new therapeutic options for the treatment of cancer.
This Research Topic intends to collect and launch a series of state-of-the-art research articles about the distinct roles of lipid and/or iron metabolism in ferroptosis and their roles in cancer. It aims to highlight significant findings and recent advances in this field. This will open up the research direction, enrich the research content, and excavate the deeper molecular and cellular mechanisms of this research area for related studies in this field.
We will welcome the submission of Original Research articles and state-of-the-art Reviews, but also Mini Reviews, Brief Research Reports, Hypotheses articles and Opinion articles that focus on but are not limited to the following:
1. The role of lipid and/or iron metabolism and ferroptosis in tumor development and drug resistance.
2. An in-depth exploration of lipid and/or iron metabolism and ferroptosis and tumor immunotherapy.
3. New targets or pathways for lipid and/or iron metabolism and ferroptosis in tumors.
4. Novel therapeutic targeting for tumor lipid and/or iron metabolism and ferroptosis.
Lipid and iron metabolism are central in ferroptosis. Their pathways are closely interrelated and play important roles in a variety of physiological and pathological processes leading to and governed by ferroptosis, and they are closely related to the occurrence and development of tumors. Targeting ferroptosis will open up new therapeutic options for the treatment of cancer.
This Research Topic intends to collect and launch a series of state-of-the-art research articles about the distinct roles of lipid and/or iron metabolism in ferroptosis and their roles in cancer. It aims to highlight significant findings and recent advances in this field. This will open up the research direction, enrich the research content, and excavate the deeper molecular and cellular mechanisms of this research area for related studies in this field.
We will welcome the submission of Original Research articles and state-of-the-art Reviews, but also Mini Reviews, Brief Research Reports, Hypotheses articles and Opinion articles that focus on but are not limited to the following:
1. The role of lipid and/or iron metabolism and ferroptosis in tumor development and drug resistance.
2. An in-depth exploration of lipid and/or iron metabolism and ferroptosis and tumor immunotherapy.
3. New targets or pathways for lipid and/or iron metabolism and ferroptosis in tumors.
4. Novel therapeutic targeting for tumor lipid and/or iron metabolism and ferroptosis.
Keywords: cancer, tumor metabolism, lipid metabolism, iron metabolism, cell death, ferroptosis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
