About this Research Topic
Vascular contributions to cognitive impairment and dementia of later life are common. Chronic cerebral hypoperfusion (CCH) plays a critical role in the progression of Vascular Cognitive Impairment and Dementia (VCID). However, CCH and CCH-related VCID remain unclear regarding pathophysiology, molecular mechanisms and treatment, due to the lack of CCH animal models. VCID, neuropathology, basic science, pathophysiology, neuroimaging, vascular risk factors, and treatment options are areas of research that are in high demand. Recent studies suggest CCH may contribute to several VCID-related pathologies in animals and patients, including neurons loss, neurodegeneration, cerebrovascular dysfunction, white matter damage, neuroinflammation, and oxidative stress. For CCH and CCH-related VCID, many molecular mechanisms and possible therapeutic targets have been proposed.
Studies on VCID mediated by CCH have not kept pace with those on Alzheimer’s disease or other pathologies of dementia. Numerous questions remain unanswered in this field. First of all, many other mechanisms underlying various pathological changes and the disease progress in CCH-related VCID have yet to be revealed. Secondly, more studies are needed to compare the disease progress and response to treatment in CCH-related VCID with different cerebrovascular risk factors and comorbidity, which is more in line with clinical practice. Moreover, appropriate animal models and clinical diagnosis of CCH and CCH-related VCID are still lacking. Finally, no specific clinical treatment is available in CCH and CCH-related VCID. It is hoped that more accurate mechanisms and more effective treatment of CCH-related VCID will be developed.
This Research Topic aims to welcome original research or reviews that contribute to progressing our knowledge on the pathology, molecular mechanisms, and treatment of CCH and CCH-related VCID. Additionally, this research topic would also like to focus on the development of animal models and diagnosis technics for CCH and CCH-related VCID. We are interested in, but not limited to, the following areas:
• Molecular mechanisms of CCH-related VCID
• Risk factors for progressive VCID mediated by CCH
• Pathology and pathogenesis of CCH
• Animal models for CCH and CCH-related VCID
• Novel diagnosis technics for CCH and CCH-related VCID
• Treatment strategies of CCH and CCH-related VCID
Studies on VCID mediated by CCH have not kept pace with those on Alzheimer’s disease or other pathologies of dementia. Numerous questions remain unanswered in this field. First of all, many other mechanisms underlying various pathological changes and the disease progress in CCH-related VCID have yet to be revealed. Secondly, more studies are needed to compare the disease progress and response to treatment in CCH-related VCID with different cerebrovascular risk factors and comorbidity, which is more in line with clinical practice. Moreover, appropriate animal models and clinical diagnosis of CCH and CCH-related VCID are still lacking. Finally, no specific clinical treatment is available in CCH and CCH-related VCID. It is hoped that more accurate mechanisms and more effective treatment of CCH-related VCID will be developed.
This Research Topic aims to welcome original research or reviews that contribute to progressing our knowledge on the pathology, molecular mechanisms, and treatment of CCH and CCH-related VCID. Additionally, this research topic would also like to focus on the development of animal models and diagnosis technics for CCH and CCH-related VCID. We are interested in, but not limited to, the following areas:
• Molecular mechanisms of CCH-related VCID
• Risk factors for progressive VCID mediated by CCH
• Pathology and pathogenesis of CCH
• Animal models for CCH and CCH-related VCID
• Novel diagnosis technics for CCH and CCH-related VCID
• Treatment strategies of CCH and CCH-related VCID
Keywords: Vascular cognitive impairment, dementia, chronic cerebral hypoperfusion, pathology, molecular mechanism, treatment
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