About this Research Topic
Translational research bridges the gap between basic research and clinical application by 'translating' scientific knowledge into practice, and is therefore essential for drug discovery and treatment ALS.
This Research Topic aims to collect a series of experimental studies on the role of molecular, cellular and systems biology factors such as neurotransmitters, synaptic plasticity, neurocytotoxicity, glial cells and animal models in the disease, focusing on their potential applications for clinical use and treatment. High level Reviews on the mechanisms of integrative therapies for the diseases are of great interest. We welcome Original Research, Brief Research Reports, Reviews, Mini-Reviews and Opinions on the following topics:
- Translational research in amyotrophic lateral sclerosis;
- Therapeutic approaches to improve symptoms and delay progression of amyotrophic lateral sclerosis;
- Mechanism of efficacy of biological agents, chemical drugs, physical therapy, stem cell therapy and natural products based on molecular biology, cellular, neurocytotoxic, glial cell and gene-based animal models;
- Translational research in cellular and animal models of amyotrophic lateral sclerosis;
- Evidence-based pattern syndrome: integrative therapies for amyotrophic lateral sclerosis;
- Pharmacogenomic evaluation of Amyotrophic Lateral Sclerosis;
- Network pharmacology of therapies for amyotrophic lateral sclerosis and modulation at the molecular level.
Keywords: amyotrophic lateral sclerosis (ALS), translational research, therapeutic approach, pharmacogenomic evaluation, integrative therapies, gene-based animal model
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.