About this Research Topic
Recent years have witnessed a remarkable increase in the incidence of cancers and despite the many advances made in therapeutics sadly there is not much improvement in the rate of mortality. Moreover, the side effects and other complications associated with the therapeutics have impacted the conditions of patients gravely. To worsen the situation, the emergence of chemoresistance in cancer cells has dampened the effectiveness of the available chemotherapy and immunotherapy approaches. The current context requires some urgent interventions to overcome these limitations. For centuries, natural products have been effectively used in the treatment of diseases and many of the present therapeutics have been derived from them. The greatest advantages natural products provide are the lack of side effects and cost-effectiveness. Furthermore, it has been observed that the derivatives of natural products have the potential to increase the efficacy of drugs if administered in combination with other drugs and can even overcome the chemoresistance. Therefore, warranting novel studies and advances in perspective to the chemosensitizing effect of natural products against cancers can broadly contribute to the scientific community and can add pace in the development of effective therapeutic approaches.
This Research Topic is mainly focused on the exploration of the chemosensitizing roles of natural products in overcoming the chemoresistance of cancer cells. This Topic aims at the studies related to the use of natural products in combination with other chemo or immunotherapeutic drugs to therapeutic limitations related to resistance. The purpose is to give more emphasis on the molecular targets and mechanistic effects of natural products in combating cancers by overcoming chemoresistance and other developed resistance. The overall goal is to discuss the latest advances made in the derivation of therapeutics from the natural products at clinical, in vivo, and in vitro level research.
We invite authors to submit original research articles, reviews, opinion, and methodologies focused on (but not limited to) the following areas are encouraged:
- Investigations relevant to the chemosensitizing effect of the natural products against cancers (active natural compounds, medicinal plant extracts, synergistic study with other drugs).
- Research with an emphasis on the mechanism of action and identification of molecular targets of natural products important for the chemosensitizing activity of natural products against cancers.
- Studies on the chemosensitizing effect of natural products in immunomodulation and/or immunotherapy against cancers.
- Randomized clinical trials that support the efficacy and application of natural products either singly or in combination with other drugs.
This Research Topic is mainly focused on the exploration of the chemosensitizing roles of natural products in overcoming the chemoresistance of cancer cells. This Topic aims at the studies related to the use of natural products in combination with other chemo or immunotherapeutic drugs to therapeutic limitations related to resistance. The purpose is to give more emphasis on the molecular targets and mechanistic effects of natural products in combating cancers by overcoming chemoresistance and other developed resistance. The overall goal is to discuss the latest advances made in the derivation of therapeutics from the natural products at clinical, in vivo, and in vitro level research.
We invite authors to submit original research articles, reviews, opinion, and methodologies focused on (but not limited to) the following areas are encouraged:
- Investigations relevant to the chemosensitizing effect of the natural products against cancers (active natural compounds, medicinal plant extracts, synergistic study with other drugs).
- Research with an emphasis on the mechanism of action and identification of molecular targets of natural products important for the chemosensitizing activity of natural products against cancers.
- Studies on the chemosensitizing effect of natural products in immunomodulation and/or immunotherapy against cancers.
- Randomized clinical trials that support the efficacy and application of natural products either singly or in combination with other drugs.
Keywords: Natural products, Cancer, Chemosensitization, Chemotherapy, Immunotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
