Olfactory subsystems in mammals: morphology, genetic and evolution

  • 15k

    Total downloads

  • 92k

    Total views and downloads

Download PDFDownload EPUB

Submit your idea

You will be redirected to our submission process.

Submit your manuscript

About this Research Topic

Submission closed

Background

The last few years have seen huge progress in the knowledge of the sense of smell that lead the scientific community to reconsider critical issues affecting the whole sensory system, and even established ideas considered fixed scientific beliefs a few years ago need to be revisited. At the same time, olfactory structures like the ganglion of Grüneberg and the septal organ, which seemed not so long ago forgotten, are now being studied in great detail using different strategies.
This renewed interest for such structures is indeed one of the factors that stand for the definition of Olfactory Subsystems, which –as the name indicate– are nothing else but divisions of the sense of smell as a whole. These divisions imply that the area receiving odorous chemical stimulation –the olfactory sensory epithelium of the nasal cavity– is divided into zones or structures.
Enough evidence supports the existence of such subdivisions or subsystems from a strictly morphological point of view and increasing number of convincing findings indicate a functional separation as well. Sensory neurons from the olfactory epithelium of the nasal cavity express different molecular markers, including receptors, G proteins, ion channels and other signal transduction molecules. Chemosignals are recognized by various types of receptors: odorant receptors, vomeronasal and formyl peptide receptors, trace amine associated receptors, guanylyl cyclases, and transient receptors potential ion channels. However, the still persisting lack of a clear connection between the morphological and molecular subdivisions, prevent us to fully understand the functional roles of each subsystem. It has not been determined whether particular types of receptor-neurons share a single location, that could be in the ganglion of Grüneberg, in the septal organ, in the vomeronasal organ (in any of the two sensorial layers), or in the main olfactory epithelium (in any of its presumptive subdivisions), or on the contrary, whether they are present in multiple locations in several of the mentioned subdivisions. Whichever of those alternatives is found to be true, it would certainly be of great interest to know how the above mentioned receptor-neurons are organized.
Specific receptors in the periphery of the olfactory system transduce the olfactory information activating defined neural circuits in the olfactory bulb and higher processing centers in the brain. It is not known whether the different subsystems have specialized as well as redundant functions in conveying chemosensory information. Gain deeper understanding on the organization of olfactory circuits is critical to provide important insights of the identity and function of the olfactory subsystems.
The conceptual definition of the olfactory subsystems will most probably be supported by the specialists as the relationship between morphology and molecular biology, two fields that should never have followed independent paths, is constantly growing.
In addition to this, the number of functional chemosensory receptor genes and pseudogenes varies enormously among the genome of the different animal species, representing an ideal structural platform to study evolution.
We welcome experts in the field to participate in this Research Topic, especially by means of ongoing original works and revision papers.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

     

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

     

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

     

Impact

  • 92kTopic views
  • 71kArticle views
  • 15kArticle downloads
View impact