Neuromodulatory Ascending Systems: Their Influence at the Microscopic and Macroscopic Levels

  • 5,646

    Total downloads

  • 32k

    Total views and downloads

About this Research Topic

Submission closed

Background

The communication between neurons within neural circuits relies on neurotransmitters (i.e.glutamate, γ-aminobutyric acid) and neuromodulators (e.g. acetylcholine, dopamine, serotonin, etc.). These chemicals, inside and outside the synapse, shape the time course of neuronal membrane potentials, which in turn affects the issuance of action potentials and the communication between neurons at different levels of brain organization. Neurotransmitters are responsible for interneuronal communication through highly localized synaptic signaling, whereas neuromodulators are sometimes extrasynaptic and more broadly mediate the efficacy of postsynaptic events: for example, changing the impact of one set of neurons on another. Such modulation is known to have important consequences for behavior, as neuromodulators are closely associated with cognitive enhancement and deficits.
The role of neuromodulatory ascending systems, while essential to nervous system function, is significantly more difficult to study than neurotransmission. That is, because the effects of neuromodulators are of slow onset, long duration, and often have effects that are more complex than simple excitation or inhibition. For instance, neuromodulators have a range of effects on the highly nonlinear dynamics of membrane properties and synapses, enabling neurons to be more flexible in their ability to encode different sorts of information (e.g., sensory information) on a variety of time scales. Importantly, the effects of neuromodulators depend critically on specific receptors, their locus inside and outside of synapses, and the intrinsic dynamics of target neurons or circuits with the consequence of directly modulating their internal state, changing their metabolic demands.
Neuromodulators that have identical action at the single-neuron level can impact circuits very differently depending on the expression, density, and distribution of receptors. One of the challenges in this work was to understand the extent to which neuromodulator actions are coordinated across multiple levels of brain function. In other words, how might combinations of neuromodulators impact or reconfigure circuits such that the same brain systems are able to support a wide range of behaviorally relevant outputs?

This Research Topic aims to disseminate recent advances in our understanding of the neural mechanisms that underlie behavior, with the focus on neuromodulator ascending pathways. Understanding the role of neuromodulatory systems not only requires the characterization of the influence of neuromodulators (e.g., acetylcholine) at the single-cell level but also requires knowledge about architecture and functioning of neural networks where it targets.

We welcome original research studies, review articles, opinion articles, and perspectives that focus on the role of neuromodulatory ascending pathway, including, but not limited to:

a) Anatomical aspects of different neuromodulatory ascending pathway
b) Neurodevelopment and synapse formation of these ascending systems
c) Neuromodulator receptors density and distributions across the brain
d) Species differences, e.g. human, rodents, non-human primates
e) Technological advances for the study of neuromodulators influence
f) The role of neuromodulator systems at the local (microcircuit level) versus the role of neuromodulator systems at a long-distance synaptic circuit, also investigating their effects on cortical activity.
g) Brain disorders associated to neuromodulatory ascending systems

Keywords: Neural Circuits, Neurophysiology & Neuroimaging, Animal Research, Clinical Neuroscience, Neuromodulatory Pathways or neuromodulation system

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

Participating Journals

Impact

  • 32kTopic views
  • 26kArticle views
  • 5,646Article downloads
View impact