About this Research Topic
Bone is a dynamic, adaptive, and self-healing system that plays numerous critical physiological functions in the vertebrates, including locomotion, supporting the body, protecting organs, hematopoietic function, storing minerals, and endocrine function. Moreover, bone is a finely mechanosensitive organ and constantly adapts its shape and internal structure to mechanical loads.
Bone development is complex progress and is formed by either intramembranous ossification or endochondral ossification. Both intramembranous ossification and endochondral ossification begin with mesenchymal stem cells (MSCs). For adult bone, bone homeostasis is orchestrated by several main types of bone cells, including MSC, osteoblast, osteoclast, and osteocyte. The osteoblast is responsible for bone formation, it is initiated from MSC and terminally differentiated into an osteocyte. The osteoclast is responsible for bone resorption. Bone homeostasis is maintained by the balance of bone formation and bone resorption. Disruption of this balance leads to bone diseases, such as osteoporosis and osteopetrosis.
Increasing evidence uncovers the involvement of bone cells in bone development, metabolism, senescence, and mechanotransduction, their crosstalk, the underlying molecular and cellular mechanisms, and their relationship with bone disease development and progression.
The focus of this Research Topic will be to provide insight into bone development, metabolism, senescence, and mechanotransduction, the underlying molecular and cellular mechanisms of these processes, and their involvement during bone disease (e.g. osteoporosis, osteoarthritis, osteosarcoma) development and progression. We welcome Original Research and Review articles that cover, but are not limited to:
• The involvement of bone cells (osteoblast, osteoclast, MSCs, osteocyte) in bone development, bone remodeling, and the underlying mechanism.
• The cellular metabolism and senescence of bone cells and their relationship with bone disease, such as osteoporosis, osteoarthritis, osteosarcoma.
• The mechanotransduction of bone cells and its involvement in bone development and bone disease development.
• Novel methods adopted for studying mechanotransduction of bone cells and bone.
• The functional crosstalk between bone cells during bone development, metabolism, senescence, and mechanotransduction.
• The effects of mechanical stimuli on bone development, metabolism, and senescence of bone.
• Novel methods for bone disease research.
• Targeting the bone cells and the related specific molecules for treating bone disease and the underlying mechanism.
Bone development is complex progress and is formed by either intramembranous ossification or endochondral ossification. Both intramembranous ossification and endochondral ossification begin with mesenchymal stem cells (MSCs). For adult bone, bone homeostasis is orchestrated by several main types of bone cells, including MSC, osteoblast, osteoclast, and osteocyte. The osteoblast is responsible for bone formation, it is initiated from MSC and terminally differentiated into an osteocyte. The osteoclast is responsible for bone resorption. Bone homeostasis is maintained by the balance of bone formation and bone resorption. Disruption of this balance leads to bone diseases, such as osteoporosis and osteopetrosis.
Increasing evidence uncovers the involvement of bone cells in bone development, metabolism, senescence, and mechanotransduction, their crosstalk, the underlying molecular and cellular mechanisms, and their relationship with bone disease development and progression.
The focus of this Research Topic will be to provide insight into bone development, metabolism, senescence, and mechanotransduction, the underlying molecular and cellular mechanisms of these processes, and their involvement during bone disease (e.g. osteoporosis, osteoarthritis, osteosarcoma) development and progression. We welcome Original Research and Review articles that cover, but are not limited to:
• The involvement of bone cells (osteoblast, osteoclast, MSCs, osteocyte) in bone development, bone remodeling, and the underlying mechanism.
• The cellular metabolism and senescence of bone cells and their relationship with bone disease, such as osteoporosis, osteoarthritis, osteosarcoma.
• The mechanotransduction of bone cells and its involvement in bone development and bone disease development.
• Novel methods adopted for studying mechanotransduction of bone cells and bone.
• The functional crosstalk between bone cells during bone development, metabolism, senescence, and mechanotransduction.
• The effects of mechanical stimuli on bone development, metabolism, and senescence of bone.
• Novel methods for bone disease research.
• Targeting the bone cells and the related specific molecules for treating bone disease and the underlying mechanism.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
