Fertility Preservation in the Pediatric Population

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About this Research Topic

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Background

Fertility preservation in children has long only been considered for those facing gonadotoxic treatments in the setting of new diagnoses of cancer. However, this field is now being expanded to include children with other conditions affecting fertility such as rheumatologic/nephrologic disease and even the transgender population, where fertility preservation counseling and discussion is in its infancy. Research regarding the optimal methods, timing, and eventual outcomes of both ovarian and testicular tissue storage in prepubertal girls and boys, respectively, as well as data on outcomes of oocyte and semen cryopreservation in adolescence is lacking. Deriving mainly from literature in adults, ovarian tissue cryopreservation has recently been deemed non-experimental; knowledge gaps still exist in the pediatric population.

This collection serves as a dedicated research publication, or part thereof, to highlight the important aspects of missing research information in pediatric fertility preservation programs and aims to advance the science considerably. Since many centers, nationally and internationally, are not even aware of best practice guidelines for pediatric fertility preservation in children facing fertility threatening diagnoses and treatment plans, disseminating knowledge regarding the same in both providers and thus the population at large, is much needed.

The Topic Editors invite:
- Best practice guidelines to consider for referral to pediatric fertility preservation programs, including indications, both oncologic and non-oncologic;
- Setting up a pediatric fertility preservation program at an academic medical center with appropriate referral channels to surrounding non-academic settings;
- Reviewing early data on successful outcomes, both in animal models and humans for ovarian tissue cryopreservation and testicular tissue cryo preservation;
- Indications and ideal timing for fertility preservation counseling and discussion as well as procedures in the transgender population.

Keywords: Tissue cryopreservation, gonadotoxicity, fertility preservation, ovary tissue storage, testicular tissue ssstirage

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