About this Research Topic
Respiratory modulation is dictated by sets of sensory neurons residing in key ganglia in the periphery and within respiratory brain-stem centers. Sensitivity to oxygen and carbon dioxide are the main drivers of reflex driven changes to breathing patterns and, a multitude of pathways confer neuronal oxygen sensitivity. Targeted modulation of neuronal sensitivity is beginning to be recognized to occur in response to a variety of stimuli and may confer specific changes to breathing pattern in response to ligands which are produced in response to homeostatic shifts. Investigation into targeted stimuli in response to various ligands may confer sensory neuron specificity and changes in breathing requires intense investigation.
The goal of this Research Topic is to decipher the regulatory processes of peripheral sensory neurons and respiratory brainstem centers. The signaling within sensory neurons and their stimulation of respiratory networks requires identification and investigation to study specific cellular subsets responsible for changes in breathing. Contributors are invited to submit work investigating specific mechanisms responsible for sensory neuron excitation and, ultimately, changes to brainstem center modulation of breathing.
This Research Topic seeks manuscripts which test: 1) sensory neuron/ neuroendocrine cell excitation involving signaling pathways (mitochondrial and/or mitochondrial microdomain signaling pathways); 2) pathophysiological stimulation of sensory neurons/ neuroendocrine cells; 3) neuronal/glial cellular changes and changes to breathing patterns; 4) metabolic changes to breathing patterns; 5) pathophysiologic changes to breathing patterns.
Topic Editor Nicholas Jendzjowsky is a co-founder and shareholders of AazeinTx Inc, a clinical-stage University spinoff company.
The goal of this Research Topic is to decipher the regulatory processes of peripheral sensory neurons and respiratory brainstem centers. The signaling within sensory neurons and their stimulation of respiratory networks requires identification and investigation to study specific cellular subsets responsible for changes in breathing. Contributors are invited to submit work investigating specific mechanisms responsible for sensory neuron excitation and, ultimately, changes to brainstem center modulation of breathing.
This Research Topic seeks manuscripts which test: 1) sensory neuron/ neuroendocrine cell excitation involving signaling pathways (mitochondrial and/or mitochondrial microdomain signaling pathways); 2) pathophysiological stimulation of sensory neurons/ neuroendocrine cells; 3) neuronal/glial cellular changes and changes to breathing patterns; 4) metabolic changes to breathing patterns; 5) pathophysiologic changes to breathing patterns.
Topic Editor Nicholas Jendzjowsky is a co-founder and shareholders of AazeinTx Inc, a clinical-stage University spinoff company.
Keywords: Oxidative phosphorylation, Mitochondria, Microdomain, Carotid body, Chemoreceptor, Petrosal ganglion, Vagus, Nodose ganglion, Jugular ganglion, Pre-botzinger, Retrotrapezoid nucleus, Parafacial respiratory group, Astrocytes, Glia, Lactate, Cytokines
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
