Gastrointestinal and Liver Effects of Fruits and their Synergism with Drug Therapy: Exploring Possible Mechanisms of Action

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About this Research Topic

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Background

Currently, there is a significant increase in demand for food and food products that provide health benefits beyond their nutritional aspects. These benefits can be used to treat or prevent several diseases through the interactions of phytoconstituents with biological targets or through antioxidant properties. Another important aspect is the synergism of therapy with drugs and phytoconstituents originating from fruits, which can modify the bioavailability or efficacy, increasing future opportunities for drug development. In addition, these phytochemicals can be incorporated as an alternative for development, with new applications for multitarget therapeutic using a better understanding of biochemical and electrical effects or molecular interaction in a biologic system.

The interaction between pharmacology and nutrition science can be considered one of the important determinants of health, utilized to prevent or treat several diseases. Therefore, understanding the subtle interactions between multi-pathway and multi-targeting approaches with fruit is essential. The purpose of this special issue is to summarize the scientific information of chemical and phytochemical constituents or derivative, traditional uses, in vitro and in vivo studies and, the therapeutic potential of the fruit or fruit residues used individually or your synergism with drug therapy to the treatment of acute or chronic diseases involving the liver or Gastrointestinal tract.

In this special issue, we aim to collect a series of high-quality reviews and original papers to highlight the huge potential molecules, extract, the fraction of fruit or fruit derivative, associated or not with drugs, in pathways and/or mechanisms of action involved in biochemistry and pharmacology, with possibilities of innovative applications and drug development. Basic or applied approaches to this main focus in silicon, ex vivo, in vitro, or in vivo, intending to investigate the beneficial therapeutic effect or toxicity effects on treating acute or chronic diseases involving the liver or Gastrointestinal tract. Theme such as, anticancer, antibacterial, antifungal, analgesic, antioxidant, antiviral, anthelmintic, anti-inflammatory, hepatoprotective, hepatotoxic, ulcer healing properties, digestive problems as spasmodic gastric-intestinal are welcome, but themes to be contemplated are not limited to this list.

Keywords: Liver, Bioactivity, Fruit, Gastro-intestinal, Therapeutic potential

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